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Table 2 Three biomarkers for total AKI and severe AKI detection

From: Evaluation of clinically available renal biomarkers in critically ill adults: a prospective multicenter observational study

Biomarkers Non-AKIa (n = 758) Total AKIa (n = 326) AUC-ROCb (95% CI)
  Severe AKIa (n = 102)  
sCysC (mg/L) 0.79 (0.62–0.98) 1.13 (0.80–1.57) 0.738 (0.703–0.772)c,d
1.49 (1.10–2.16) 0.839 (0.798–0.880)c,d
uNAG (U/g Cre) 22.63 (13.21–37.93) 35.28 (20.36–66.53) 0.650 (0.614–0.686)e
46.73 (25.64–75.07) 0.706 (0.651–0.761)d,e
uACR (mg/g Cre) 23.90 (11.54–60.30) 73.65 (22.41–264.90) 0.683 (0.648–0.718)e
187.82 (54.75–428.71) 0.771 (0.726–0.817)c,e
  1. Abbreviations: AKI Acute kidney injury, sCysC, Serum cystatin C, uNAG Urinary N-acetyl-β-d-glucosaminidase, Cre Creatinine concentration, uACR Urinary albumin/creatinine ratio
  2. a The nonnormally distributed continuous variables are expressed as median (25th percentile to 75th percentile [interquartile range])
  3. b Values are presented as AUC-ROC (95% confidence interval)
  4. c P < 0.05 vs. uNAG
  5. d P < 0.05 vs. uACR
  6. e P < 0.05 vs. sCysC