Evaluation of clinically available renal biomarkers in critically ill adults: a prospective multicenter observational study

Table 2 Three biomarkers for total AKI and severe AKI detection

Biomarkers	Non-AKI^a (n = 758)	Total AKI^a (n = 326)	AUC-ROC^b (95% CI)
Biomarkers		Severe AKI^a (n = 102)
sCysC (mg/L)	0.79 (0.62–0.98)	1.13 (0.80–1.57)	0.738 (0.703–0.772)^c,d
sCysC (mg/L)	0.79 (0.62–0.98)	1.49 (1.10–2.16)	0.839 (0.798–0.880)^c,d
uNAG (U/g Cre)	22.63 (13.21–37.93)	35.28 (20.36–66.53)	0.650 (0.614–0.686)^e
uNAG (U/g Cre)	22.63 (13.21–37.93)	46.73 (25.64–75.07)	0.706 (0.651–0.761)^d,e
uACR (mg/g Cre)	23.90 (11.54–60.30)	73.65 (22.41–264.90)	0.683 (0.648–0.718)^e
uACR (mg/g Cre)	23.90 (11.54–60.30)	187.82 (54.75–428.71)	0.771 (0.726–0.817)^c,e

Abbreviations: AKI Acute kidney injury, sCysC, Serum cystatin C, uNAG Urinary N-acetyl-β-d-glucosaminidase, Cre Creatinine concentration, uACR Urinary albumin/creatinine ratio
^a The nonnormally distributed continuous variables are expressed as median (25th percentile to 75th percentile [interquartile range])
^b Values are presented as AUC-ROC (95% confidence interval)
^c P < 0.05 vs. uNAG
^d P < 0.05 vs. uACR
^e P < 0.05 vs. sCysC

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