Table 2 Univariate analysis of characteristics of 88 patients on admission with sepsis in relation to the effected tumour necrosis factor-α production on day 3 by peripheral blood mononuclear cells after stimulation with bacterial lipopolysaccharide
TNF-α production ≤250 pg/ml (n = 42) | TNF-α production >250 pg/ml (n = 46) | p Value | |
|---|---|---|---|
Male sex, n (%) | 16 (38.1) | 26 (56.5) | 0.093 |
Age, years mean ± SD | 69.7 ± 12.2 | 69.6 ± 19.6 | 0.755 |
APACHE II score, mean ± SD | 15.36 ± 8.13 | 11.63 ± 7.20 | 0.025 |
PaO2/FiO2, mmHg, mean ± SD | 322.6 ± 150.5 | 302.5 ± 99.9 | 0.570 |
White blood cells, count/mm3, mean ± SD | 13,735.0 ± 7725.3 | 15,007.2 ± 7102.4 | 0.418 |
Lymphocytes, count/mm3, mean ± SD) | 1170.0 ± 697.2 | 1218.1 ± 644.2 | 0.805 |
C-reactive protein, mg/L, mean ± SD | 152.2 ± 104.3 | 110.0 ± 90.6 | 0.135 |
Type of infection, n (%) | |||
Acute pyelonephritis | 17 (40.5) | 23 (50.0) | 0.399 |
Acute intra-abdominal infection | 16 (38.1) | 13 (28.3) | 0.370 |
Gram-negative bacteraemia | 9 (21.4) | 10 (21.7) | 0.901 |
Type of failing organ, n (%) | |||
Acute respiratory distress syndrome | 5 (10.9) | 9 (21.4) | 0.245 |
Acute coagulopathy | 8 (17.4) | 2 (4.8) | 0.093 |
Acute kidney injury | 5 (10.9) | 4 (9.5) | 1.000 |
Cardiovascular failure | 1 (2.2) | 9 (21.4) | 0.006 |
At least one chronic disorder, n (%) | 28 (66.7) | 23 (50.0) | 0.134 |
At least one predisposing condition, n (%) | 15 (35.7) | 24 (52.2) | 0.138 |