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Table 2 Univariate analysis of characteristics of 88 patients on admission with sepsis in relation to the effected tumour necrosis factor-α production on day 3 by peripheral blood mononuclear cells after stimulation with bacterial lipopolysaccharide

From: Decreased cytokine production by mononuclear cells after severe gram-negative infections: early clinical signs and association with final outcome

  TNF-α production ≤250 pg/ml (n = 42) TNF-α production >250 pg/ml (n = 46) p Value
Male sex, n (%) 16 (38.1) 26 (56.5) 0.093
Age, years mean ± SD 69.7 ± 12.2 69.6 ± 19.6 0.755
APACHE II score, mean ± SD 15.36 ± 8.13 11.63 ± 7.20 0.025
PaO2/FiO2, mmHg, mean ± SD 322.6 ± 150.5 302.5 ± 99.9 0.570
White blood cells, count/mm3, mean ± SD 13,735.0 ± 7725.3 15,007.2 ± 7102.4 0.418
Lymphocytes, count/mm3, mean ± SD) 1170.0 ± 697.2 1218.1 ± 644.2 0.805
C-reactive protein, mg/L, mean ± SD 152.2 ± 104.3 110.0 ± 90.6 0.135
Type of infection, n (%)
 Acute pyelonephritis 17 (40.5) 23 (50.0) 0.399
 Acute intra-abdominal infection 16 (38.1) 13 (28.3) 0.370
 Gram-negative bacteraemia 9 (21.4) 10 (21.7) 0.901
Type of failing organ, n (%)
 Acute respiratory distress syndrome 5 (10.9) 9 (21.4) 0.245
 Acute coagulopathy 8 (17.4) 2 (4.8) 0.093
 Acute kidney injury 5 (10.9) 4 (9.5) 1.000
 Cardiovascular failure 1 (2.2) 9 (21.4) 0.006
At least one chronic disorder, n (%) 28 (66.7) 23 (50.0) 0.134
At least one predisposing condition, n (%) 15 (35.7) 24 (52.2) 0.138
  1. Abbreviations: APACHE Acute Physiology and Chronic Health Evaluation, PaO 2 /FiO 2 Ratio of partial pressure arterial oxygen and fraction of inspired oxygen, TNF-α Tumour necrosis factor-α