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Table 3 Results of random-effects logistic regression analysis to examine the effect of temporal changes in catecholamine levels on 6-month outcome of isolated TBI

From: Catecholamines as outcome markers in isolated traumatic brain injury: the COMA-TBI study

  Mortality p value Unfavorable p value
OR (95% CI) OR (95% CI)
Epinephrine
 Unadjusted
  Between-subjects 5.91 (3.58–9.75) <0.001 2.18 (1.59–2.99) <0.001
  Within-subjects 0.84 (0.73–0.84) 0.02 0.96 (0.87–1.07) 0.47
 Adjusteda
  Between-subjects 5.99 (2.93–12.22) <0.001 1.57 (1.06–2.33) <0.001
  Within-subjects 0.89 (0.73–1.08) 0.24 0.99 (0.87–1.13) 0.87
Norepinephrine
 Unadjusted
  Between-subjects 5.14 (3.29–8.03) <0.001 3.55 (2.43–5.22) <0.001
  Within-subjects 0.82 (0.70–0.96) 0.02 0.99 (0.87–1.13) 0.86
 Adjusteda
  Between-subjects 3.40 (1.93–5.99) <0.001 2.34 (1.46–3.73) 0.001
  Within-subjects 0.78 (0.63–0.97) 0.02 1.03 (0.88–1.21) 0.69
  1. aAdjusted to age, Glasgow Coma Scale and pupillary reactivity
  2. Abbreviations: TBI traumatic brain injury, OR odds ratio, CI confidence interval