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Table 2 Diagnostic accuracy of Hemochron® Signature POCT for rivaroxaban

From: Point-of-care testing for emergency assessment of coagulation in patients treated with direct oral anticoagulants

Coagulation test result Threshold (ng/mL) Specificity (%) Sensitivity (%) LR PPV (%) NPV (%)
POCT PT ≤1.0 <30 97 (89–100) 33 (20–48) 11.6 88 69
POCT PT ≤1.1 <100 96 (85–99) 38 (27–50) 9.0 93 52
POCT ACT+ ≤120 s <30 96 (87–99) 67 (52–80) 15.7 91 82
POCT ACT+ ≤130 s <100 96 (85–99) 68 (55–78) 16.2 96 68
  1. n = 118 samples
  2. Sensitivity and specificity are provided with 95% confidence intervals
  3. ACT+ activated clotting time plus, LR likelihood ratio, NPV negative predictive value, POCT point of care test, PPV positive predictive value, PT prothrombin time