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Table 2 SOFA derivatives used as endpoints

From: SOFA and mortality endpoints in randomized controlled trials: a systematic review and meta-regression analysis

SOFA derivative

Description

Included RCTs

Fixed-day SOFA

SOFA score on a fixed day after randomization

58a

 Early fixed-day SOFA

SOFA score on days 2, 3, 4 or 5 after randomization

55a

 Late fixed-day SOFA

SOFA score on days 7, 10 or 14 after randomization

32a

Delta SOFA

Trajectory of SOFA score from baseline

25

 Delta fixed-day SOFA

SOFA score on a fixed day after randomization minus baseline SOFA score

18

 Delta maximum SOFA

Maximum SOFA score during ICU stay minus baseline SOFA score

7

Other SOFA derivatives

 

 Maximum SOFA

Maximum SOFA score during ICU stay

9

 Mean SOFA

Mean SOFA score during ICU stay

3

 Discharge SOFA

SOFA score at ICU discharge or death

3

  1. aTwenty-nine trials reported both early and late SOFA scores. SOFA sequential organ failure assessment