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Table 2 SOFA derivatives used as endpoints

From: SOFA and mortality endpoints in randomized controlled trials: a systematic review and meta-regression analysis

SOFA derivative Description Included RCTs
Fixed-day SOFA SOFA score on a fixed day after randomization 58a
 Early fixed-day SOFA SOFA score on days 2, 3, 4 or 5 after randomization 55a
 Late fixed-day SOFA SOFA score on days 7, 10 or 14 after randomization 32a
Delta SOFA Trajectory of SOFA score from baseline 25
 Delta fixed-day SOFA SOFA score on a fixed day after randomization minus baseline SOFA score 18
 Delta maximum SOFA Maximum SOFA score during ICU stay minus baseline SOFA score 7
Other SOFA derivatives  
 Maximum SOFA Maximum SOFA score during ICU stay 9
 Mean SOFA Mean SOFA score during ICU stay 3
 Discharge SOFA SOFA score at ICU discharge or death 3
  1. aTwenty-nine trials reported both early and late SOFA scores. SOFA sequential organ failure assessment