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Table 2 Respiratory mechanics for the patients during mechanical ventilation at various tidal volumes (\( \overline{\mathrm{x}} \) ± s, n = 19)

From: The effects of low tidal ventilation on lung strain correlate with respiratory system compliance

  VT (ml/kg)
  6 8 10 12
PEEPtot, cmH2O
 C ≥ 0.6 (n = 9) 8.3 ± 1.6 8.3 ± 1.6 8.3 ± 1.6 8.1 ± 1.6
 C < 0.6 (n = 10) 8.1 ± 1.9 8.1 ± 2.0 8.1 ± 2.0 8.1 ± 2.0
Ppeak, cmH2O
 C ≥ 0.6 (n = 9) 20.1 ± 4.4 24.4 ± 4.0 31.3 ± 5.7* 34.9 ± 4.9*
 C < 0.6 (n = 10) 27.1 ± 3.9 31.0 ± 4.9# 33.9 ± 4.9* 35.6 ± 5.3*
Pplat, cmH2O
 C ≥ 0.6 (n = 9) 15.7 ± 2.5 19.3 ± 2.5* 22.3 ± 3.1* 24.4 ± 2.3*
 C < 0.6 (n = 10) 21.8 ± 2.6# 25.6 ± 4.1# 26.7 ± 3.2*# 27.6 ± 2.6*#
Pmean, cmH2O
 C ≥ 0.6 (n = 9) 10.1 ± 2.5 11.1 ± 2.0 12.6 ± 2.4 13.0 ± 2.1
 C < 0.6 (n = 10) 12.6 ± 3.5 14.3 ± 4.9 14.6 ± 4.9 14.8 ± 4.8
EELV, ml
 C ≥ 0.6 (n = 9) 2804 ± 1562 2717 ± 1124 2628 ± 1086 2534 ± 1048
 C < 0.6 (n = 10) 1317 ± 775# 1347 ± 886# 1485 ± 840# 1482 ± 1230
C, ml/(cmH2O/kg)
 C ≥ 0.6 (n = 9) 0.85 ± 0.23 0.75 ± 0.14 0.70 ± 0.11 0.73 ± 0.10
 C < 0.6 (n = 10) 0.45 ± 0.08# 0.40 ± 0.16# 0.48 ± 0.10# 0.47 ± 0.09#
  1. Abbreviations: V T tidal volume PEEPtot total positive-end expiratory pressure, Ppeak peak airway pressure, Pplat plateau pressure, Pmean mean airway pressure, EELV end-expiratory lung volume, C respiratory system compliance
  2. # p < 0.05 for the comparison with C ≥ 0.6 subjects
  3. * p <0.05 for the comparison with VT = 6 ml/kg PBW