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Table 2 Comparison of hemodynamic characteristics 18 hours after cecal ligation and puncture using echocardiography

From: Effects of low doses of esmolol on cardiac and vascular function in experimental septic shock

Variables

CLP

IQR

CLP + E-1

IQR

CLP + E-5

IQR

CLP + E-18

IQR

P value

Post hoc analysis

n = 8

n = 8

n = 8

n = 8

Median

Min–Max

Median

Min–Max

Median

Min–Max

Median

Min–Max

Heart rate (min−1)

419

349–472

381–452

429

392–456

414–436

419

396–434

402–428

366

342–383

354–376

0.002

1.000: CLP vs. CLP + E-1

1.000: CLP vs. CLP + E-5

0.019: CLP vs. CLP + E-18

Mean arterial pressure (mmHg)

74

59–83

67–81

89

86–92

88–90

90

77–97

85–95

82

71–114

78–87

0.001

0.002: CLP vs. CLP + E-1

0.005: CLP vs. CLP + E-5

0.624: CLP vs. CLP + E-18

LVIDs (mm)

2.76

0.99–4.07

2.26–3.46

3.35

2.75–3.77

3.00–3.73

3.67

2.89–3.97

3.10–3.93

3.21

2.04–3.97

2.98–3.33

0.118

 

LVIDd (mm)

5.41

2.70–7.38

4.99–6.24

6.86

6.13–7.33

6.63–7.23

7.14

6.10–7.88

6.58–7.68

6.64

5.86–7.38

6.38–6.79

0.008

0.090: CLP vs. CLP + E-1

0.012: CLP vs. CLP + E-5

0.679: CLP vs. CLP + E-18

Stroke volume (μl)

92

71–144

73–120

207

153–225

172–220

215

154–238

183–234

160

142–215

148–209

<0.001

0.002: CLP vs. CLP + E-1

<0.001: CLP vs. CLP + E-5

0.092: CLP vs. CLP + E-18

Cardiac output (ml.min−1)

43

25–58

29–49

86

66–97

76–94

89

66–101

74–97

60

49–80

53–75

<0.001

<0.001: CLP vs. CLP + E-1

<0.001: CLP vs. CLP + E-5

0.528: CLP vs. CLP + E-18

Ejection fraction (%)

88

51–94

84–92

86

83–92

85–90

86

83–89

84–88

87

83–95

86–89

0.685

 

Lactatemia (mmol.l−1)

2.5

1.6–3.5

2.1–2.8

1.3

0.7–1.5

1.2–1.4

1.4

0.6–2.0

1.0–1.5

1.6

1.2–2.4

1.3–1.9

0.001

0.001: CLP vs. CLP + E-1

0.007: CLP vs. CLP + E-5

0.128: CLP vs. CLP + E-18

  1. Data were analyzed using the Kruskal-Wallis test. When significant at the 5% level, post hoc comparisons were performed between CLP and CLP + E-1, CLP + E-5, CLP + E-18 groups using Dunn’s multiple-comparisons test. CLP cecal ligation and puncture, Min–Max minimum–maximum, IQR interquartile range, CLP + E-1 CLP + esmolol at 1 mg.kg−1.h−1, CLP + E-5 CLP + esmolol at 5 mg.kg−1.h−1, CLP + E-18 CLP + esmolol at 18 mg.kg−1.h−1, LVIDs left ventricular internal diameter end systole, LVIDd left ventricular internal diameter end diastole