Table 1 Baseline participant characteristics by HDL-C and LDL-C quartile
From: Cholesterol levels and long-term rates of community-acquired sepsis
Characteristic | HDL-C quartile | LDL-C quartile | ||||||
|---|---|---|---|---|---|---|---|---|
Q1, 5–40 mg/dl | Q2, 41–49 mg/dl | Q3, 50–61 mg/dl | Q4, 62–199 mg/dl | Q1, 3–89 mg/dl | Q2, 90–111 mg/dl | Q3, 112–135 mg/dl | Q4, 136–388 mg/dl | |
Number of participants | 7305 | 7064 | 7162 | 6749 | 6984 | 7088 | 6915 | 6896 |
Demographics | ||||||||
Age (years), mean (SD) | 64.8 (9.3) | 64.8 (9.5) | 64.8 (9.3) | 65.1 (9.5) | 66.3 (9.5) | 65.4 (9.5) | 64.5 (9.4) | 63.4 (9.0) |
Age group (%) | ||||||||
 45–49 | 5.0 | 5.5 | 4.8 | 4.6 | 4.4 | 4.7 | 5.4 | 5.4 |
 50–59 | 26.0 | 25.5 | 26.5 | 26.8 | 20.8 | 24.7 | 27.9 | 31.3 |
 60–69 | 38.2 | 38.3 | 37.8 | 36.3 | 37.0 | 37.7 | 37.1 | 38.5 |
 70–79 | 24.3 | 23.4 | 24.2 | 24.6 | 28.9 | 25.1 | 23.0 | 19.8 |
 ≥80 | 6.6 | 7.3 | 6.6 | 7.7 | 8.8 | 7.9 | 6.7 | 5.0 |
Gender (%) | ||||||||
 Male | 71.3 | 51.6 | 35.3 | 21.7 | 51.1 | 47.1 | 43.6 | 38.9 |
 Female | 28.7 | 48.4 | 64.7 | 78.3 | 48.9 | 52.9 | 56.4 | 61.1 |
Race (%) | ||||||||
 White | 67.6 | 58.8 | 55.7 | 55.5 | 62.3 | 61.3 | 58.6 | 54.6 |
 Black | 32.4 | 41.3 | 44.3 | 44.5 | 37.7 | 38.7 | 41.4 | 45.5 |
Education (%) | ||||||||
 Less than high school | 13.1 | 12.8 | 12.4 | 10.9 | 13.5 | 11.8 | 11.8 | 12.1 |
 High school graduate | 25.8 | 26.4 | 26.4 | 24.6 | 26.1 | 25.4 | 24.4 | 27.3 |
 Some college | 27.2 | 26.6 | 26.9 | 26.5 | 26.0 | 26.7 | 27.8 | 26.7 |
 College or higher | 34.0 | 34.2 | 34.3 | 38.1 | 34.5 | 36.2 | 36.1 | 33.9 |
 Missing (N) | 7 | 4 | 3 | 7 | 7 | 4 | 3 | 7 |
Income (%) | ||||||||
  < $20,000 | 16.6 | 18.3 | 18.0 | 17.7 | 18.2 | 16.9 | 16.5 | 18.7 |
 $20,000–34,000 | 24.0 | 24.0 | 24.9 | 23.5 | 25.2 | 24.0 | 22.9 | 24.4 |
 $35,000–74,000 | 32.1 | 30.8 | 29.1 | 28.0 | 29.8 | 30.8 | 30.7 | 29.1 |
  ≥ $75,000 | 16.6 | 15.5 | 15.5 | 16.4 | 15.0 | 16.2 | 17.3 | 15.6 |
 Refused | 10.7 | 11.4 | 12.5 | 14.4 | 11.9 | 12.1 | 12.6 | 12.2 |
Geographic region (%) | ||||||||
 Stroke buckle | 20.7 | 20.6 | 21.7 | 20.9 | 22.4 | 20.7 | 20.4 | 20.2 |
 Stroke belt | 37.0 | 35.7 | 33.7 | 32.6 | 35.1 | 35.1 | 33.7 | 34.9 |
 Nonbelt/buckle | 42.3 | 43.7 | 44.7 | 46.5 | 42.5 | 44.2 | 46.0 | 44.9 |
Health behaviors | ||||||||
 Smoking status (%) | ||||||||
  Current | 17.1 | 15.1 | 13.2 | 12.1 | 14.1 | 13.1 | 14.2 | 15.8 |
  Past | 44.9 | 41.1 | 38.3 | 37.1 | 44.4 | 40.9 | 39.1 | 36.9 |
  Never | 38.1 | 43.9 | 48.5 | 50.9 | 41.5 | 46.0 | 46.7 | 47.2 |
  Missing (N) | 17 | 29 | 31 | 28 | 23 | 24 | 31 | 25 |
 Alcohol use (%) | ||||||||
  Heavy | 1.8 | 3.1 | 4.0 | 7.5 | 4.0 | 4.4 | 3.9 | 3.7 |
  Moderate | 31.8 | 32.5 | 33.5 | 36.7 | 32.3 | 35.0 | 34.8 | 32.0 |
  None | 66.4 | 64.4 | 62.5 | 55.9 | 63.7 | 60.6 | 61.3 | 64.3 |
  Missing (N) | 155 | 153 | 106 | 134 | 145 | 140 | 122 | 130 |
Chronic medical conditions | ||||||||
 Cancer (%) | 10.3 | 8.5 | 8.0 | 8.0 | 10.2 | 9.3 | 8.0 | 7.2 |
 Chronic lung disease (%) | 8.3 | 9.2 | 9.2 | 10.0 | 10.7 | 9.7 | 8.8 | 7.4 |
 Coronary artery disease (%) | 25.3 | 19.2 | 15.1 | 11.5 | 28.7 | 18.7 | 12.9 | 10.7 |
 Diabetes (%) | 30.3 | 25.4 | 19.0 | 14.2 | 33.5 | 22.9 | 17.0 | 14.8 |
 Hypertension (%) | 63.5 | 60.8 | 58.0 | 53.7 | 67.0 | 60.2 | 55.9 | 52.3 |
 Obesity (%) | 61.7 | 57.2 | 53.6 | 40.0 | 54.5 | 52.0 | 52.3 | 54.0 |
 Stroke (%) | 7.6 | 7.0 | 5.7 | 4.4 | 8.5 | 6.3 | 5.0 | 4.9 |
 Statin use (%) | 35.3 | 35.2 | 31.6 | 23.6 | 56.6 | 47.0 | 36.8 | 37.0 |
Biomarkers | ||||||||
 hs-CRP > 3.0 mg/dl | 44.6 | 41.8 | 40.3 | 35.5 | 38.3 | 39.6 | 40.8 | 43.8 |
  Missing (N) | 148 | 165 | 167 | 179 | 150 | 177 | 159 | 160 |
 Cystatin C > 1.12 mg/dl | 34.1 | 26.7 | 21.6 | 17.3 | 32.1 | 25.7 | 22.2 | 19.7 |
  Missing (N) | 183 | 187 | 208 | 212 | 189 | 199 | 196 | 191 |
 ACR > 30 μg/mg (%) | 18.8 | 15.7 | 13.0 | 12.5 | 17.5 | 15.0 | 13.7 | 13.3 |
  Missing (N) | 267 | 308 | 249 | 254 | 295 | 287 | 227 | 250 |
 eGFR < 60 ml/min/1.73 m2 | 14.7 | 11.8 | 10.3 | 8.7 | 15.2 | 11.9 | 9.7 | 8.8 |
  Missing (N) | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Functional status | ||||||||
 Weakness (SF-12 PCS < 75) (%) | 31.0 | 29.9 | 28.8 | 26.7 | 33.8 | 28.9 | 26.5 | 26.8 |
 Reported exhaustion (%) | 15.7 | 13.9 | 13.4 | 11.7 | 14.8 | 14.1 | 12.4 | 13.0 |
 Low physical activity (%) | 34.7 | 33.5 | 33.6 | 32.6 | 35.4 | 33.7 | 32.6 | 32.6 |