Article/outcomes | Survival | Complications | Severity score | Cut-off |
---|---|---|---|---|
Nonspecific trauma | ||||
Ren et al. [37] | NA | Not able to predict secondary infection | No significant correlation between cfDNA and ISS | 700 copies/L plasma sensitivity: 41.1% specificity: 96.7% PPV: 95.85% NPV: 46.8% |
Margraf et al. [15] | Lower levels of cfDNA had a NPV of 100% for MOF and death | Higher levels of cfDNA on admission and on days 7–10 was significantly associated with sepsis | Higher levels of cfDNA correlated with higher ISS scores. | NA |
Lo et al. [14] | All patients undergoing death had significantly higher cfDNA than survivors | ALI and ARDS patients had significantly higher cfDNA than patients without this diagnosis | Higher levels of cfDNA correlated with higher ISS scores. | 232.719 KE/L had a sensitivity and specificity for death of 78% and 82%, respectively |
Wijeratne et al. [39] | 2.3-fold higher cfDNA in nonsurvivors than in survivors (no p value) | Ventilated patients had significantly higher cfDNA values than nonventilated patients | Higher levels of cfDNA correlated with higher SOFA scores but not with APACHE II | 6.109 GE/mL sensitivity and specificity at 85% and 80%, respectively, for death |
Lam et al. [29] | Study 1: NA Study 2: NA | Study 1: statistical difference between patients with OF and nonOF patients Study 2: on days 2, 3, 4, and 5 patients with MODS had significantly higher cfDNA that nonMODS patients | Study 1: At 1 h, 2 h, 3 h cfDNA significantly higher in patients with severe injury compared to less severely injured patients. Study 2: NA | NA |
McIlroy et al. [43] | Not powered | No correlation between levels of mtDNA or nDNA in relation to SIRS or MOF | Not powered | Not powered |
Yamanouchi et al. [34] | Significantly higher mtDNA in nonsurvivors compared to survivors (2 patients died) | No correlation with SOFA or APACHE II scores | High mtDNA significantly correlated with high ISS score (p < 0.05) | NA |
Lam et al. [36] | Significantly higher mtDNA in nonsurvivors compared to survivors (2 patients died) | NA | Patients with severe injury (ISS >16) had significantly higher mtDNA than patients with minor/moderate injury (ISS < 16). Similar results for nDNA | NA |
Gu et al. [35] | NA | mtDNA on ICU admission able to predict SIRS (p < 0.001) | mtDNA significantly correlated to high APACHE II score(p = 0.034) and ISS score (p < 0.001) | Cut-off value of mtDNA 1.3185 μg/ml with a sensitivity of 67% and specificity of 75% |
Traumatic brain injury | ||||
Macher et al. [30] | Significantly higher decrease of cfDNA from 0 to 24 h in survivors than in nonsurvivors | Patients with high GCS score (11–15) had significantly lower serum DNA levels at admission and 24 h than severe TBI patients | Patients with high APACHE II (<15) score and ISS had significantly higher cfDNA that patients with lower APACHE II score and ISS at 24 h | A cut-off ratio of 1.95 had a sensitivity and specificity of 70% and 66%, respectively |
Shaked et al. [31] | Significantly higher levels of cfDNA in nonsurvivors than in survivors | Significantly higher cfDNA in patients with GOS score ≤4 vs patients with GOS score 5 | A cut-off ratio of 700 ng/ml had a sensitivity and specificity of 82% and 59% to predict GOS <5 | |
Yurgel et al. [32] | Significantly higher levels of cfDNA at 24 h in nonsurvivors than in survivors | No difference in cfDNA between isolated TBI and TBI with extracranial injuries | 77,883,5 KE/L at 24 h with a sensitivity and specificity of 67% and 76% for mortality | |
Filho et al. [33] | Significantly higher levels of cfDNA in nonsurvivors than in survivors | High cfDNA levels on admission siginificantly associated with death | Significantly higher cfDNA in patients with lower GCS score compared with patients with higher GCS score | 171.381 KE/L plasma sensitivity of 43%, specificity of 90% |
Wang et al. [16] | nDNA had significantly higher levels on days 1, 4, and 7 in patients with poor outcome compared to patients with good outcome | High nDNA significantly correlated with low GCS | High nDNA significantly correlated with high ISS score | 72.95 ng/ml sensitivity of 87.5%, specificity of 86.2% |