Table 4 Odds ratios of stage-3 progression in time categories below each threshold MAP
|  | All patients (n = 538) | Sepsis (n = 138) | Non-sepsis (n = 400) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Number/total number (%) | Adjusted ORa (95% CI) | Number/total number (%) | Adjusted ORb (95% CI) | Number/total number (%) | Adjusted ORb (95% CI) | |||||||
Stage-3 progression | 54/538 | (10.0) | – | – | 27/138 | (19.6) | – | – | 27/400 | (6.8) | – | – |
 Time spent < MAP 65 mm Hg | ||||||||||||
  None (0 h) | 17/266 | (6.4) | 1.00 | Reference | 9/65 | (13.8) | 1.00 | Reference | 8/201 | (4.0) | 1.00 | Reference |
  0–3 h | 23/216 | (10.6) | 1.47 | (0.71–3.06) | 14/60 | (23.3) | 1.57 | (0.60–4.13) | 9/156 | (5.8) | 1.59 | (0.52–4.90) |
  3–6 h | 14/56 | (25.0) | 3.73 | (1.53–9.09) | 4/13 | (30.8) | 2.60 | (0.61–11.00) | 10/43 | (23.3) | 4.53 | (1.35–15.30) |
 Time spent < MAP 70 mm Hg | ||||||||||||
  None (0 h) | 9/167 | (5.4) | 1.00 | Reference | 6/40 | (15.0) | 1.00 | Reference | 3/127 | (2.4) | 1.00 | Reference |
  0–3 h | 25/228 | (11.0) | 1.51 | (0.64–3.60) | 14/67 | (20.9) | 1.10 | (0.37–3.33) | 11/161 | (6.8) | 3.04 | (0.70–13.20) |
  3–6 h | 20/143 | (14.0) | 2.35 | (0.96–5.78) | 7/31 | (22.6) | 1.45 | (0.41–5.13) | 13/112 | (11.6) | 4.42 | (1.03–19.00) |
 Time spent < MAP 75 mm Hg | ||||||||||||
  None (0 h) | 6/109 | (5.5) | 1.00 | Reference | 3/23 | (13.0) | 1.00 | Reference | 3/86 | (3.5) | 1.00 | Reference |
  0–3 h | 14/165 | (8.5) | 1.53 | (0.52–4.48) | 10/47 | (21.3) | 1.86 | (0.44–7.99) | 4/118 | (3.4) | 1.13 | (0.21–6.12) |
  3–6 h | 34/264 | (12.9) | 1.92 | (0.72–5.15) | 14/68 | (20.6) | 1.42 | (0.35–5.88) | 20/196 | (10.2) | 2.78 | (0.66–11.60) |