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Table 3 Blood pressure parameters within 6 h after oliguric AKI diagnosis

From: Early-phase cumulative hypotension duration and severe-stage progression in oliguric acute kidney injury with and without sepsis: an observational study

 

All patients (n = 538)

Sepsis (n = 138)

Non-sepsis (n = 400)

Stage-3 progression

No progression

P value

Stage-3 progression

No progression

P value

Stage-3 progression

No progression

P value

(n = 54)

(n = 484)

 

(n = 27)

(n = 111)

 

(n = 27)

(n = 373)

 

Time-averaged MAP (mm Hg (IQR))

71 (65–77)

75 (70–83)

0.003

73 (70–81)

75 (71–83)

0.356

70 (62–74)

75 (69–83)

0.001

Lowest MAP (mm Hg (IQR))

61 (55–67)

65 (60–73)

0.002

62 (59–68)

65 (59–72)

0.301

59 (53–66)

65 (60–73)

0.001

Area under threshold MAP (hours × mm Hg (IQR))

 65 mm Hg

2.0 (0.0–10.2)

0.0 (0.0–3.5)

0.001

1.0 (0.0–6.8)

0.0 (0.0–3.4)

0.159

4.0 (0.0–24.1)

0.0 (0.0–3.5)

0.001

 70 mm Hg

10.0 (1.6–29.8)

3.3 (0.0–14.5)

0.001

7.5 (0.8–18.4)

3.3 (0.0–12.4)

0.219

15.5 (4.3–50.8)

3.5 (0.0–15.5)

0.001

 75 mm Hg

27.8 (10.9–57.4)

14.4 (0.9–37.0)

0.001

25.5 (5.6–40.0)

15.0 (1.5–33.8)

0.221

39.5 (19.4–78.6)

14.1 (0.8–37.7)

<0.001

Time below threshold MAP (hours (IQR))

 65 mm Hg

0.5 (0.0–3.2)

0.0 (0.0–1.0)

0.002

0.3 (0.0–1.4)

0.0 (0.0–0.9)

0.157

0.8 (0.0–4.0)

0.0 (0.0–1.0)

0.003

 70 mm Hg

2.4 (0.8–4.8)

1.0 (0.0–3.0)

0.002

1.8 (0.4–3.3)

1.0 (0.0–2.8)

0.271

2.8 (1.5–5.8)

0.8 (0.0–3.3)

0.001

 75 mm Hg

4.6 (2.1–5.7)

2.8 (0.5–5.0)

0.002

3.5 (1.5–5.4)

2.8 (0.5–4.8)

0.263

5.5 (3.4–5.9)

2.8 (0.5–5.2)

0.001

  1. AKI acute kidney injury; IQR interquartile range, MAP mean arterial pressure