| All patients (n = 538) | Sepsis (n = 138) | Non-sepsis (n = 400) | ||||||
---|---|---|---|---|---|---|---|---|---|
Stage-3 progression | No progression | P value | Stage-3 progression | No progression | P value | Stage-3 progression | No progression | P value | |
(n = 54) | (n = 484) |  | (n = 27) | (n = 111) |  | (n = 27) | (n = 373) |  | |
Time-averaged MAP (mm Hg (IQR)) | 71 (65–77) | 75 (70–83) | 0.003 | 73 (70–81) | 75 (71–83) | 0.356 | 70 (62–74) | 75 (69–83) | 0.001 |
Lowest MAP (mm Hg (IQR)) | 61 (55–67) | 65 (60–73) | 0.002 | 62 (59–68) | 65 (59–72) | 0.301 | 59 (53–66) | 65 (60–73) | 0.001 |
Area under threshold MAP (hours × mm Hg (IQR)) | |||||||||
 65 mm Hg | 2.0 (0.0–10.2) | 0.0 (0.0–3.5) | 0.001 | 1.0 (0.0–6.8) | 0.0 (0.0–3.4) | 0.159 | 4.0 (0.0–24.1) | 0.0 (0.0–3.5) | 0.001 |
 70 mm Hg | 10.0 (1.6–29.8) | 3.3 (0.0–14.5) | 0.001 | 7.5 (0.8–18.4) | 3.3 (0.0–12.4) | 0.219 | 15.5 (4.3–50.8) | 3.5 (0.0–15.5) | 0.001 |
 75 mm Hg | 27.8 (10.9–57.4) | 14.4 (0.9–37.0) | 0.001 | 25.5 (5.6–40.0) | 15.0 (1.5–33.8) | 0.221 | 39.5 (19.4–78.6) | 14.1 (0.8–37.7) | <0.001 |
Time below threshold MAP (hours (IQR)) | |||||||||
 65 mm Hg | 0.5 (0.0–3.2) | 0.0 (0.0–1.0) | 0.002 | 0.3 (0.0–1.4) | 0.0 (0.0–0.9) | 0.157 | 0.8 (0.0–4.0) | 0.0 (0.0–1.0) | 0.003 |
 70 mm Hg | 2.4 (0.8–4.8) | 1.0 (0.0–3.0) | 0.002 | 1.8 (0.4–3.3) | 1.0 (0.0–2.8) | 0.271 | 2.8 (1.5–5.8) | 0.8 (0.0–3.3) | 0.001 |
 75 mm Hg | 4.6 (2.1–5.7) | 2.8 (0.5–5.0) | 0.002 | 3.5 (1.5–5.4) | 2.8 (0.5–4.8) | 0.263 | 5.5 (3.4–5.9) | 2.8 (0.5–5.2) | 0.001 |