Early-phase cumulative hypotension duration and severe-stage progression in oliguric acute kidney injury with and without sepsis: an observational study

Table 1 Staging of acute kidney injury for adults according to KDIGO

Staging	Serum creatinine	Urine output
Stage 1	1.5–1.9 times baseline, or ≥0.3 mg/dL (≥26.5 μmol/L) increase	<0.5 mL/kg/h for 6–12 h^a
Stage 2	2.0–2.9 times baseline	<0.5 mL/kg/h for ≥12 h
Stage 3	3.0 times baseline, or increase in serum creatinine to ≥4.0 mg/dL (≥353.6 μmol/L), or initiation of renal replacement therapy	<0.3 mL/kg/h for ≥24 h^b, or anuria for ≥12 h^b

Acute kidney injury (AKI) is defined as any of the following: (1) increase in serum creatinine by ≥0.3 mg/dL (≥26.5 μmol/L) within 48 h; (2) increase in serum creatinine by ≥1.5 times baseline, which is known or presumed to have occurred within the prior 7 days; (3) urine output <0.5 mL/kg/h for 6 h. AKI was diagnosed according to the Kidney Disease Improving Global Outcomes (KDIGO). ^aDefinition of stage-1 oliguric AKI in this study. ^bDefinition of stage-3 oliguric AKI (progression to oligoanuria and use of renal replacement therapy) in this study

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