Skeletal muscle quality as assessed by CT-derived skeletal muscle density is associated with 6-month mortality in mechanically ventilated critically ill patients

Table 3 Cox regression: association between skeletal muscle density or intermuscular adipose tissue and mortality

	Univariable N = 491			Model 2 N = 491			Model 3 N = 491			Model 4 (n = 337)
6-month mortality	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value
SMD (per 10 HU)	0.640	0.552–0.742	<0.001	0.703	0.605–0.818	<0.001	0.774	0.643–0.931	0.006	0.728	0.571–0.928	0.010
IMAT (per 10 cm²)	1.153	1.042–1.277	0.006	1.092	0.980–1.217	0.110	1.092	0.966–1.236	0.159	1.244	1.048–1.476	0.012

Model 2: adjusted for APACHE II score
Model 3: adjusted for APACHE II score, skeletal muscle area, and BMI
Model 4 (subgroup analysis): adjusted for APACHE II score, skeletal muscle area, visceral adipose tissue, and subcutaneous adipose tissue
Values in bold indicate statistically significant p values
APACHE Acute Physiological, Age, and Chronic Health Evaluation, CI confidence interval, HR hazard ratio, HU Hounsfield Units, IMAT intermuscular adipose tissue, SMD skeletal muscle density

ISSN: 1364-8535