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Table 1 Patient characteristics of all patients and comparison between survivors and non-survivors

From: Skeletal muscle quality as assessed by CT-derived skeletal muscle density is associated with 6-month mortality in mechanically ventilated critically ill patients

 

All patients

N = 491

Survivors1

(n = 299)

Non-survivors1

(n = 165)

P value survivors vs. non-survivors

 

Mean/median/n

SD/IQR/%

Mean/median/n

SD/IQR/%

Mean/median/n

SD/IQR/%

 

Age, years

58

±18

55

±18

67

±14

<0.001

Sex, male, n (%)

305

62%

191

64%

93

56%

0.135

BMI, kg/m2

25.2

±4.3

25.5

±4.4

24.6

±4.3

0.042

 Underweight2, n (%)

19

4.1%

11

3.7%

8

4.8%

0.291

 Normal weight2, n (%)

238

51.3%

145

48.5%

93

56.4%

 

 Overweight2, n (%)

158

34.1%

108

36.1%

50

30.3%

 

 Obesity2, n (%)

49

10.6%

35

11.7%

14

8.5%

 

APACHE II score

24

±8

22

±8

27

±8

<0.001

Admission category, n (%)

      

0.001

 Medical

248

50.5%

130

43%

102

62%

 

 Surgical

243

49.5%

169

57%

63

38%

 

Admission diagnosis, n (%)

      

<0.001

 Cardiovascular

32

6.5%

18a

6.0%

14a

8.5%

 

 Metabolic/renal

15

3.1%

8a

2.7%

6a

3.6%

 

 Neurologic

41

8.4%

19a

6.4%

16a

9.7%

 

 Post-resuscitation

28

5.7%

16a

5.4%

11a

6.7%

 

 Post-surgery

149

30.3%

95a

31.8%

50a

30.3%

 

 Respiratory insufficiency

68

13.8%

40a

13.4%

25a

15.2%

 

 Sepsis

31

6.3%

14a

4.7%

15a

9.1%

 

 Trauma

94

19.1%

74a

24.7%

13b

7.9%

 

 Other

33

6.7%

15a

5.0%

15a

9.1%

 

Length of hospital stay before ICU admission, days

0

0–4

0

0–4

0

0–6

0.166

Time from ICU admission to CT scan, days

0

0–1

0

0–1

0

0–1

0.277

Skeletal muscle area, cm2

136.5

±39.0

143.5

±38.9

120.3

±33.0

<0.001

Skeletal muscle index, cm2/m2

44.8

±11.0

46.6

±10.6

40.4

±9.9

<0.001

Low skeletal muscle area3, n (%)

312

63.5%

163

54.5%

137

83.0%

<0.001

SMD, HU

29.9

±11.7

31.4

±11.7

25.1

±9.4

<0.001

IMAT, cm2

13.6

8.4–24.3

13.3

7.9–23.2

17.1

10.5–27.1

0.004

Visceral adipose tissue, cm2 (n = 337)

96.7

49.3–170.6

95.8

50.9–178.1

108.1

54.1–177.5

0.593

Subcutaneous adipose tissue, cm2 (n = 337)

132.7

90.2–182.4

133.7

89.8–189.2

127.7

95.7–176.2

0.440

  1. 1Survivors and non-survivors 6 months after ICU admission
  2. 2WHO categories: underweight, BMI <18.5; normal weight: BMI 18.5–24.9; overweight: BMI 25–29.9; obesity: BMI ≥30 [42]
  3. 3Defined by skeletal muscle area: <170 cm2 for males and <110 cm2 for females [9]
  4. a, bValues in the same row not sharing the same superscript letter are significantly different in a post-hoc Bonferroni analysis
  5. Values in bold indicate statistically significant p values
  6. APACHE Acute Physiological, Age, and Chronic Health Evaluation, BMI, body mass index, CT computed tomography, HU Hounsfield Units, ICU intensive care unit, IMAT intermuscular adipose tissue, IQR interquartile range, SD standard deviation, SMD skeletal muscle density