Table 2 Postoperative outcomes: effects of perioperative statin therapy versus control
From: Perioperative statin therapy in cardiac surgery: a meta-analysis of randomized controlled trials
Postoperative outcome | Number of trials | Number of patients | OR (95% CI) | P value | Trial sequential analysis | Level of evidence |
|---|---|---|---|---|---|---|
Acute kidney injury | ||||||
 Trials with low risk of bias | 3 | 2637 | 1.26 (1.05, 1.52) | 0.01 | Conclusive: harmful of statins | High |
 All trials | 10 | 3354 | 1.18 (0.99, 1.41)a | 0.06 | Inconclusive | Low |
Atrial fibrillation | ||||||
 Trials with low risk of bias | 2 | 2537 | 1.08 (0.90, 1.30) | 0.40 | Conclusive: futility of statins | Moderate |
 All trials | 19 | 4737 | 0.80 (0.70, 0.91)a | 0.001 | Inconclusive | Very low |
Myocardial infarction | ||||||
 Trials with low risk of bias | 2 | 2537 | 0.97 (0.71, 1.33) | 0.87 | Conclusive: futility of statins | Moderate |
 All trials | 18 | 4151 | 0.92 (0.69, 1.23)a | 0.56 | Conclusive: futility of statins | Very low |
Stroke | ||||||
 Trials with low risk of bias | 2 | 2537 | 1.25 (0.58, 2.70) | 0.56 | Conclusive: futility of statins | Low |
 All trials | 11 | 3499 | 1.09 (0.60, 2.00) | 0.77 | Conclusive: futility of statins | Very low |
Infections | ||||||
 Trials with low risk of bias | 2 | 2537 | 0.80 (0.60, 1.07) | 0.14 | Inconclusive | Low |
 All trials | 7 | 2724 | 0.78 (0.59, 1.04) | 0.09 | Conclusive: futility of statins | Very low |
Mortality | ||||||
 Trials with low risk of bias | 3 | 2637 | 3.84 (0.95, 15.55) | 0.06 | Inconclusive | Low |
 All trials | 18 | 4157 | 1.92 (0.79, 4.66) | 0.15 | Inconclusive | Very low |