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Table 2 Postoperative outcomes: effects of perioperative statin therapy versus control

From: Perioperative statin therapy in cardiac surgery: a meta-analysis of randomized controlled trials

Postoperative outcome Number of trials Number of patients OR (95% CI) P value Trial sequential analysis Level of evidence
Acute kidney injury
 Trials with low risk of bias 3 2637 1.26 (1.05, 1.52) 0.01 Conclusive: harmful of statins High
 All trials 10 3354 1.18 (0.99, 1.41)a 0.06 Inconclusive Low
Atrial fibrillation
 Trials with low risk of bias 2 2537 1.08 (0.90, 1.30) 0.40 Conclusive: futility of statins Moderate
 All trials 19 4737 0.80 (0.70, 0.91)a 0.001 Inconclusive Very low
Myocardial infarction
 Trials with low risk of bias 2 2537 0.97 (0.71, 1.33) 0.87 Conclusive: futility of statins Moderate
 All trials 18 4151 0.92 (0.69, 1.23)a 0.56 Conclusive: futility of statins Very low
Stroke
 Trials with low risk of bias 2 2537 1.25 (0.58, 2.70) 0.56 Conclusive: futility of statins Low
 All trials 11 3499 1.09 (0.60, 2.00) 0.77 Conclusive: futility of statins Very low
Infections
 Trials with low risk of bias 2 2537 0.80 (0.60, 1.07) 0.14 Inconclusive Low
 All trials 7 2724 0.78 (0.59, 1.04) 0.09 Conclusive: futility of statins Very low
Mortality
 Trials with low risk of bias 3 2637 3.84 (0.95, 15.55) 0.06 Inconclusive Low
 All trials 18 4157 1.92 (0.79, 4.66) 0.15 Inconclusive Very low
  1. aEvidence of publication bias in favor of statins. Italics indicate statistical significance. OR odds ratio, CI confidence interval