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Table 1 Characteristics of the trials included in the analysis

From: Perioperative statin therapy in cardiac surgery: a meta-analysis of randomized controlled trials

Trial Journal Cardiac surgery procedure Number of patients Statin Statin regimen Duration of preoperative therapy Control Patients naïve to statin therapy? Outcomes for meta-analysis Risk of bias
Almansob 2012 [31] Arterioscler Thromb Vasc Biol Non coronary cardiac surgery 132 Simvastatin 20 mg 5–7 days preop and from day 2 postop (no day 0) 5–7 days No treatment NR AF, MI, S, M High
Baran 2012 [32] Stem Vell Rev and Rep CABG 60 Atorvastatin 40 mg 2 weeks preop and postop (no day 0) 2 weeks Placebo Yes (>3 months) AKI, AF, MI, S, M High
Berkan 2009 [33] Thorac Cardiov Surg CABG 46 Fluvastatin 80 mg 3 weeks preop 3 weeks Placebo Yes (>1 year) MI High
Billings 2016 [21] JAMA CABG (49%), valve, or ascending aortic surgery 615 Atorvastatin 40 mg Bid day 1b, qd day 0, and qd postop 2 days Placebo No (Naïve 32%) AKI, AF, MI, S, M, I Low
Caorsi 2008 [34] Eur Cytokine Netw On-pump CABG 43 Pravastatin 40 mg 2 days preop, 1 hour after CPB, and 7 days postop 2 days No treatment NR AF High
Carrascal 2016 [51] J Arrhythm Valve surgery 90 Atorvastatin 40 mg 7 days preop and 7 days postop 7 days No treatment Yes AKI, AF, MI, S, M High
Castaño 2015 [35] J Cardiovasc Surg On-pump CABG 30 Pravastatin 80 or 40 mg 2 hours before surgery 1 days Placebo No (Naïve 0%) AF, MI, M Unclear
Chello 2006 [36] Crit Care Med On-pump CABG 40 Atorvastatin 20 mg 3 weeks preop 3 weeks Placebo Yes (>1 year) AKI, AF, MI, S, M, I Unclear
Christenson 1999 [37] Eur J Cardiothorac Surg On-pump CABG 77 Simvastatin 20 mg 4 weeks preop 4 weeks No treatment NR AKI, MI, M, I High
Dehghani 2015 [38] J Cardiovasc Pharmacol Ther Valve surgery 58 Atorvastatin 40 mg 3 days preop and 5 days postop 3 days Placebo Yes AF, MI, S, M Unclear
Ji 2009 [39] Circ J Off-pump CABG 140 Atorvastatin 20 mg 7 days preop 7 days Placebo Yes AF, MI, S, M High
Mannacio 2008 [40] J Thorac Cardiovasc Surg On-pump CABG 200 Rosuvastatin 20 mg 7 days preop 7 days Placebo Yes (>1 month) AKI, AF, MI, S, M, I High
Melina 2009 [41]a Eur Heart J On- off-pump CABG 632 Atorvastatin 40 mg NR NR Placebo NR AF High
Park 2016 [42] Intensive Care Med Valve surgery 200 Atorvastatin 40 mg Bid day 1, qd day 0, and qd 3 days postopb 2 days Placebo Yes AKI, AF, MI, S, M Unclear
Patti 2006 [43] Circulation On-pump cardiac surgery (CABG 79%) 200 Atorvastatin 40 mg 7 days preop and postop until discharge (no day 0) 7 days Placebo Yes (>1 year) AF, MI, M High
Prowle 2012 [44] Nephrology On-pump cardiac surgery (CABG 57%) 100 Atorvastatin 40 mg Days 0 and 3 days postop 1 days Placebo No (Naïve 30%) AKI, M Low
Song 2008 [45] Am Heart J Off-pump CABG 124 Atorvastatin 20 mg 3 days preop, after surgery, and 30 days postop 3 days No treatment Yes AF, MI, S High
Spadaccio 2010 [46] J Cardiovasc Pharmacol On-pump CABG 50 Atorvastatin 20 mg 3 weeks preop 3 weeks Placebo Yes (>1 year) AKI, AF, MI, S, M, I Unclear
Sun 2011 [47] Int Heart J On-pump CABG 100 Atorvastatin 20 mg 7 days preop 7 days Placebo Yes (>14 days) AF, MI High
Tamayo 2009 [50] J Thorac Cardiovasc Surg On-pump CABG 44 Simvastatin 20 mg 3 weeks preop 3 weeks No treatment Yes (>3 weeks) AF, M High
Vukovic 2011 [48] Perfusion On-pump CABG 57 Atorvastatin 20 mg 3 weeks preop 3 weeks Placebo Yes (>1 year) AF, MI, M, I High
Youn 2011 [49] Korean J Thorac Cardiovasc Surg Off-pump CABG 142 Rosuvastatin 20 mg Bid day 1, qd day 0 2 days No treatment No (Naïve 45%) MI, M High
Zheng 2016 [22] N Engl J Med On-pump CABG (42%), off-pump CABG (43%), AVR, AVR + CABG 1922 Rosuvastatin 20 mg 1–8 days preop and 5 days postop 8 days Placebo No (Naïve 66%) AKI, AF, MI, S, M, I Low
  1. aAbstract-only publication. bPatients on chronic statin therapy received study drug only on day 0 and day 1, resuming chronic statin therapy on postoperative day 2. CABG coronary artery bypass grafting, AVR aortic valve replacement, CPB cardiopulmonary bypass, preop preoperative regimen, postop postoperative regimen, day 0 the morning of the day of surgery, qd once a day, bid twice a day, AF atrial fibrillation, AKI acute kidney injury, MI myocardial infarction, I infection, M mortality, NR not reported