Antipsychotic prescribing patterns during and after critical illness: a prospective cohort study

Table 2 Characteristics according to discharge on antipsychotic

Characteristics^a	Antipsychotic discontinued before discharge N = 130	Antipsychotic prescribed at discharge N = 42	p
Age, years	57 (48–69)	60 (52–71)	0.20
Female, N (%)	61 (46.9)	21 (50)	0.73
Caucasian, N (%)	122 (93.9)	38 (90.5)	0.49
Baseline cognitive impairment, N (%)^b	20 (15.4)	7 (16.7)	0.84
Charlson Comorbidity Index	2 (1–4)	2 (1–3)	0.35
ICU type, N (%)			0.55
Medical	75 (57.7)	22 (52.4)
Surgical	55 (42.3)	20 (47.6)
ICU length of stay, days	7 (4–14)	9 (4–12)	0.94
Delirium
Prevalence during study period, N (%)	120 (92)	40 (95)	0.52
Duration, days	4 (2–8)	6 (3–9)	0.12
Antipsychotic received, N (%)^c
Atypical	61 (46.9)	39 (92.9)	<0.001
Haloperidol	106 (81.5)	23 (54.8)	<0.001
Discharge disposition, N (%)			0.08
Home	60 (46.2)	12 (28.6)
Long-term acute care hospital	13 (10.0)	6 (14.3)
Rehabilitation facility	38 (29.2)	15 (35.7)
Nursing home	7 (5.4)	6 (14.3)
Other	12 (9.2)	3 (7.1)

^aValues are shown as median (interquartile range) unless otherwise noted
^bPatients with a Short IQCODE score ≥3.3 were considered to have pre-existing cognitive impairment of mild to moderate severity. We excluded patients from study enrollment with dementia that prevented them from living independently and/or with a Clinical Dementia Rating (CDR) score of 3 or more, indicative of severe dementia
^cPercentages sum to >100% because 50 patients received two different antipsychotics, and 14 patients received three different antipsychotics
ICU intensive care unit, IQCODE Informant Questionnaire of Cognitive Decline in the Elderly

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