Effect of driving pressure on mortality in ARDS patients during lung protective mechanical ventilation in two randomized controlled trials

Table 2 Multivariate Cox regression analysis for factors including driving pressure at day 1 associated with ARDS mortality at day 90

Variables	Hazard ratio (95% CI)	p
Age, per year	1.04 (1.03–1.05)	<0.001
SOFA score on day 1, per unit	1.07 (1.03–1.11)	<0.001
Continuous NMBA as allocation group, (reference is yes)	0.64 (0.45–0.91)	0.012
Continuous prone position as allocation group (reference is yes)	0.68 (0.47–0.98)	0.037
Respiratory rate on day 1, per unit	1.01 (0.98–1.03)	0.698
PaO₂/FiO₂ on day 1, per unit	1.00 (0.99–1.01)	0.831
Arterial pH on day 1, per unit	0.057 (0.009–0.371)	0.003
Lactate on day 1, per unit	18.44 (1.39–244.00)	0.027
Interaction between lactate and arterial pH on day 1, per unit	0.67 (0.47–0.96)	0.030
Driving pressure on day 1, per unit	1.05 (1.02–1.08)	0.005

Driving pressure was calculated as the difference between plateau pressure and applied positive end-expiratory pressure (PEEP). Day 1 was defined as the 24 hours following the inclusion. CI confidence intervals, SOFA sequential organ failure assessment, NMBA neuromuscular blocking agent, PaO ₂ /FIO ₂ ratio of the partial pressure of arterial oxygen to the fraction of inspired oxygen

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