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Table 2 Use of microRNAs as diagnostic or prognostic markers

From: The involvement of regulatory non-coding RNAs in sepsis: a systematic review

      

95% CI

 
 

No. of subjects (n)

Specimen

Sensitivity (%)

Specificity (%)

AUC

Lower bound

Upper bound

Reference

Diagnostic markers

 miR-146a

SIRS (14) vs sepsis (14)

Plasma

60

87.5

0.813

0.608

1.017

[51]

 miR-15a

Healthy people (32) vs severe sepsis (62)

Plasma

n/a

n/a

0.7

0.57

0.84

[15]

 miR-27a

Healthy people (32) vs severe sepsis (62)

Plasma

n/a

n/a

0.66

0.52

0.8

[15]

 miR-34a

Healthy people (32) vs severe sepsis (62)

Plasma

n/a

n/a

0.67

0.53

0.8

[15]

 miR-15a + 27a + 34a

Healthy people (32) vs severe sepsis (62)

Plasma

n/a

n/a

0.78

0.66

0.9

[15]

 miR-150

Healthy (21) vs SIRS (22) vs sepsis (23)

Whole blood

72.7

85.7

0.83

n/a

n/a

[16]

 miR4772-5p-iso

Healthy (21) vs SIRS (22) vs sepsis (23)

Whole blood

68.2

71.4

0.76

n/a

n/a

[16]

 miR-25

SIRS (30) vs sepsis (70)

Whole blood

n/a

n/a

0.806

0.701

0.912

[17]

 miR-15a

SIRS (32) vs sepsis (166)

Serum

68.3

94.4

0.858

0.8

0.916

[18]

 miR-16

SIRS (32) vs sepsis (166)

Serum

n/a

n/a

0.55

0.455

0.644

[18]

 miR-223

Normal control (24) vs sepsis (166)

Whole blood

38.21

83.72

0.608

0.519

0.697

[19]

 miR-499-5p

Normal control (24) vs sepsis (166)

Whole blood

68.29

65.12

0.686

0.592

0.779

[19]

 miR-126

SIRS (30) vs sepsis (50)

Serum

n/a

n/a

0.607

0.448

0.766

[21]

 miR-146a

SIRS (30) vs sepsis (50)

Serum

63.3

100

0.804

0.679

0.928

[21]

 miR-223

SIRS (30) vs sepsis (50)

Serum

80

100

0.858

0.748

0.968

[21]

 miR-15a

Neonates with RTI (41) vs septic neonates (46)

Serum

n/a

n/a

0.854

n/a

n/a

[53]

 miR-15b

Neonates with RTI (41) vs septic neonates (46)

Serum

n/a

n/a

0.629

n/a

n/a

[53]

 miR-16

Neonates with RTI (41) vs septic neonates (46)

Serum

n/a

n/a

0.869

n/a

n/a

[53]

 miR-223

Neonates with RTI (41) vs septic neonates (46)

Serum

n/a

n/a

0.632

n/a

n/a

[53]

Change of miRNA associated with poor prognosis

 ↓miR-25

SIRS (30) vs sepsis (70)

Whole blood

n/a

n/a

0.756

0.569

0.833

[17]

 ↑miR-155

Healthy people (30) vs septic patients (60)

Whole blood

n/a

n/a

0.763

0.626

0.901

[71]

 ↓miR-574-5p

Sepsis survivors (12) vs sepsis nonsurvivors (12)

Serum

54.55

96.15

0.736

0.646

0.827

[127]

  1. CI confidence interval, miRNA microRNA, n/a not available, RTI respiratory tract infection, SIRS systemic inflammatory response syndrome
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