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Table 2 Use of microRNAs as diagnostic or prognostic markers

From: The involvement of regulatory non-coding RNAs in sepsis: a systematic review

       95% CI  
  No. of subjects (n) Specimen Sensitivity (%) Specificity (%) AUC Lower bound Upper bound Reference
Diagnostic markers
 miR-146a SIRS (14) vs sepsis (14) Plasma 60 87.5 0.813 0.608 1.017 [51]
 miR-15a Healthy people (32) vs severe sepsis (62) Plasma n/a n/a 0.7 0.57 0.84 [15]
 miR-27a Healthy people (32) vs severe sepsis (62) Plasma n/a n/a 0.66 0.52 0.8 [15]
 miR-34a Healthy people (32) vs severe sepsis (62) Plasma n/a n/a 0.67 0.53 0.8 [15]
 miR-15a + 27a + 34a Healthy people (32) vs severe sepsis (62) Plasma n/a n/a 0.78 0.66 0.9 [15]
 miR-150 Healthy (21) vs SIRS (22) vs sepsis (23) Whole blood 72.7 85.7 0.83 n/a n/a [16]
 miR4772-5p-iso Healthy (21) vs SIRS (22) vs sepsis (23) Whole blood 68.2 71.4 0.76 n/a n/a [16]
 miR-25 SIRS (30) vs sepsis (70) Whole blood n/a n/a 0.806 0.701 0.912 [17]
 miR-15a SIRS (32) vs sepsis (166) Serum 68.3 94.4 0.858 0.8 0.916 [18]
 miR-16 SIRS (32) vs sepsis (166) Serum n/a n/a 0.55 0.455 0.644 [18]
 miR-223 Normal control (24) vs sepsis (166) Whole blood 38.21 83.72 0.608 0.519 0.697 [19]
 miR-499-5p Normal control (24) vs sepsis (166) Whole blood 68.29 65.12 0.686 0.592 0.779 [19]
 miR-126 SIRS (30) vs sepsis (50) Serum n/a n/a 0.607 0.448 0.766 [21]
 miR-146a SIRS (30) vs sepsis (50) Serum 63.3 100 0.804 0.679 0.928 [21]
 miR-223 SIRS (30) vs sepsis (50) Serum 80 100 0.858 0.748 0.968 [21]
 miR-15a Neonates with RTI (41) vs septic neonates (46) Serum n/a n/a 0.854 n/a n/a [53]
 miR-15b Neonates with RTI (41) vs septic neonates (46) Serum n/a n/a 0.629 n/a n/a [53]
 miR-16 Neonates with RTI (41) vs septic neonates (46) Serum n/a n/a 0.869 n/a n/a [53]
 miR-223 Neonates with RTI (41) vs septic neonates (46) Serum n/a n/a 0.632 n/a n/a [53]
Change of miRNA associated with poor prognosis
 ↓miR-25 SIRS (30) vs sepsis (70) Whole blood n/a n/a 0.756 0.569 0.833 [17]
 ↑miR-155 Healthy people (30) vs septic patients (60) Whole blood n/a n/a 0.763 0.626 0.901 [71]
 ↓miR-574-5p Sepsis survivors (12) vs sepsis nonsurvivors (12) Serum 54.55 96.15 0.736 0.646 0.827 [127]
  1. CI confidence interval, miRNA microRNA, n/a not available, RTI respiratory tract infection, SIRS systemic inflammatory response syndrome