The involvement of regulatory non-coding RNAs in sepsis: a systematic review

Table 1 Summary of search results

Themes	No. of studies^a	Key cellular pathways involved
Altered miRNA expression	28	Integrin signaling, leukocyte extravasation, apoptosis
Immune dysfunction	31	TNF-α/TLR/NF-κB
Endothelial dysfunction	7	MAPK/EGR, AP1/ NF-κB
Cardiopulmonary impairment	20	JNK PPARγ
Defects in other major organs	12	cAMP, Hxm1
Biomarkers (in vitro, in vivo, and clinical evidence)	28	Various
Therapeutic agents	17	Various

^aThe total number of studies is not equal to 128 due to multiple themes addressed by the same article
AP1 activator protein 1, cAMP cyclic adenosine monophosphate, EGR early growth response, JNK cJun NH2-terminal kinase, MAPK mitogen-activated protein kinase, miRNA microRNA, NF nuclear factor, PPAR peroxisome proliferator-activated receptor, TLR Toll-like receptor, TNF tumor necrosis factor

ISSN: 1364-8535