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Table 1 Summary of search results

From: The involvement of regulatory non-coding RNAs in sepsis: a systematic review

Themes No. of studiesa Key cellular pathways involved
Altered miRNA expression 28 Integrin signaling, leukocyte extravasation, apoptosis
Immune dysfunction 31 TNF-α/TLR/NF-κB
Endothelial dysfunction 7 MAPK/EGR, AP1/ NF-κB
Cardiopulmonary impairment 20 JNK PPARγ
Defects in other major organs 12 cAMP, Hxm1
Biomarkers (in vitro, in vivo, and clinical evidence) 28 Various
Therapeutic agents 17 Various
  1. aThe total number of studies is not equal to 128 due to multiple themes addressed by the same article
  2. AP1 activator protein 1, cAMP cyclic adenosine monophosphate, EGR early growth response, JNK cJun NH2-terminal kinase, MAPK mitogen-activated protein kinase, miRNA microRNA, NF nuclear factor, PPAR peroxisome proliferator-activated receptor, TLR Toll-like receptor, TNF tumor necrosis factor