Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death

Table 6 Adjusted relative risk for in-hospital mortality within KDIGO acute kidney injury stage by trajectory of acute kidney injury within group 2

KDIGO AKI stage	AKI Subphenotype	n (%)	Deaths, n (%)	RR^a (95% CI)
No AKI	–	573 (31)	62 (10.8)
Stage 1	Resolving	610 (33)	70 (11.5)	1.0 (reference)
Stage 1	Nonresolving	334 (17)	78 (23.4)	2.06 (1.52–2.80)
Stage 2	Resolving	131 (7)	21 (16.0)	1.0 (reference)
Stage 2	Nonresolving	34 (2)	14 (41.2)	2.41 (1.36–4.29)
Stage 3	Resolving	134 (7)	24 (17.9)	1.0 (reference)
Stage 3	Nonresolving	51 (3)	15 (29.4)	1.59 (0.87–2.92)

AKI Acute kidney injury, KDIGO Kidney Disease: Improving Global Outcomes, RR Relative risk
p for interaction between KDIGO stage and trajectory on risk of death: p = 0.035
^a Adjusted for age, sex, race (all white), body mass index, diabetes mellitus, Sepsis-related Organ Failure Assessment without renal component, vasopressors, sepsis

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