Skip to main content

Table 2 Evolution of all biomarkers

From: Mid-regional pro-adrenomedullin (MR-proADM), a marker of positive fluid balance in critically ill patients: results of the ENVOL study

Biomarkers Normal values (min-max) Day 2 Day 5 Day 7
Number M (25–75) Number M (25–75) Number M (25–75)
Angiotensin II (pmol/L) 19–38 58 21 (8–38) 65 9 (6–18)* 67 9 (5–12)**
Renin (pg/mL) 3–16 67 52 (14–93) 65 15 (6–64)* 67 14 (6–36)**
Aldosterone (pg/mL) 42–201 67 33 (14–111) 65 47 (19–105) 67 54 (16–127)
Pro-ANP (pmol/L) <85 67 54 (31–110) 65 68 (48–105) 67 59 (34–97)
Pro-endothelin (pmol/L) 34–55 67 62 (47–83) 65 59 (50–70) 67 53 (43–73)
CT-proAVP (pmol/L) 1.1–16.4 67 19 (11–43) 65 13 (6–22)* 67 11 (5–21)*
MR-proADM (nmol/L) <0.39 67 1.05 (0.79–1.85) 65 1.05 (0.75–1.46) 67 0.76 (0.6–1.15)*¥
Cortisol (ng/dL) 9–22 67 19 (14–27) 64 22 (18–27) 67 23 (19–28)
Epinephrin (pg/mL) <80 66 89 (50–152) 65 95 (60–184) 67 113(55–180)
Norepinephrine (pg/mL)a <450 67 1773 (630–4100) 65 762 (448–1473) 67 705 (437–1326)
EPO (mUI/mL) 6.4–63.8 66 52 (27–90) 65 38 (22–65) 67 28 (17–38)**¥
  1. Min-max are the lowest and highest normal values. M (25–75) is median (interquartile 25–75 range). aNo statistical analysis was performed because norepinephrine was used as a treatment in a significant number of patients (n = 30 at day 2 (D2), n = 12 at D5 and n = 10 at D7). ANP atrial natriuretic peptide, MR-proADM mid-regional pro-adrenomedullin, EPO erythropoietin. * P < 0.01 vs D2; ** P < 0.001 vs D2; ¥ P < 0.05 vs D5