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Table 2 Evolution of all biomarkers

From: Mid-regional pro-adrenomedullin (MR-proADM), a marker of positive fluid balance in critically ill patients: results of the ENVOL study

Biomarkers

Normal values (min-max)

Day 2

Day 5

Day 7

Number

M (25–75)

Number

M (25–75)

Number

M (25–75)

Angiotensin II (pmol/L)

19–38

58

21 (8–38)

65

9 (6–18)*

67

9 (5–12)**

Renin (pg/mL)

3–16

67

52 (14–93)

65

15 (6–64)*

67

14 (6–36)**

Aldosterone (pg/mL)

42–201

67

33 (14–111)

65

47 (19–105)

67

54 (16–127)

Pro-ANP (pmol/L)

<85

67

54 (31–110)

65

68 (48–105)

67

59 (34–97)

Pro-endothelin (pmol/L)

34–55

67

62 (47–83)

65

59 (50–70)

67

53 (43–73)

CT-proAVP (pmol/L)

1.1–16.4

67

19 (11–43)

65

13 (6–22)*

67

11 (5–21)*

MR-proADM (nmol/L)

<0.39

67

1.05 (0.79–1.85)

65

1.05 (0.75–1.46)

67

0.76 (0.6–1.15)*¥

Cortisol (ng/dL)

9–22

67

19 (14–27)

64

22 (18–27)

67

23 (19–28)

Epinephrin (pg/mL)

<80

66

89 (50–152)

65

95 (60–184)

67

113(55–180)

Norepinephrine (pg/mL)a

<450

67

1773 (630–4100)

65

762 (448–1473)

67

705 (437–1326)

EPO (mUI/mL)

6.4–63.8

66

52 (27–90)

65

38 (22–65)

67

28 (17–38)**¥

  1. Min-max are the lowest and highest normal values. M (25–75) is median (interquartile 25–75 range). aNo statistical analysis was performed because norepinephrine was used as a treatment in a significant number of patients (n = 30 at day 2 (D2), n = 12 at D5 and n = 10 at D7). ANP atrial natriuretic peptide, MR-proADM mid-regional pro-adrenomedullin, EPO erythropoietin. * P < 0.01 vs D2; ** P < 0.001 vs D2; ¥ P < 0.05 vs D5