Author, year | Population | Design | Number of patients | Age (mean) | Male (%) | APACHE II (mean) | MV | Intervention (daily caloric intake) | Control (daily caloric intake) | Duration of intervention |
---|---|---|---|---|---|---|---|---|---|---|
Montecalvo et al., 1992 [54]a | Medical and surgical | RCT | 38 | 50.5 years in the intervention group, 44.8 years in the control group | 60.5 | Acute physiology score of APACHE II 24.0 in the intervention group, 21.7 in the control group | Not reported Probably all | Jejunal feeding (1182 ± 603 kcal; 46.9 ± 25.9 % of goal) | Gastric feeding (1466 ± 398 kcal; 61.0 ± 17 % of goal) | As long as tube feeding was required Mean tube feeding was 10 days |
Kearns et al., 2000 [55] | Medical | RCT | 44 | 54 years in the intervention group, 49 years in the control group | 68 | 22 in the intervention group, 20 in the control group | 100 % | Small intestinal feeding (1157 ± 86 kcal; 18 ± 1 kcal/kg/day; 69 ± 7 % of caloric requirement) Protein intake: 0.7 ± 0.1 g/kg/kg/day | Gastric feeding (812 ± 122 kcal; 12 ± 2 kcal/kg/day; 47 ± 7 % of caloric requirement). Protein intake 0.4 ± 0.1 g/kg/kg/day | 7–10 days |
Chen et al., 2006 [56]a | Medical | RCT | 107 | Similar age distribution in the control and intervention groups | 76.6 | Similar APACHE II distribution in both groups | 100Â % | Continuous feeding, with calories significantly different from the other group | Intermittent feeding | Not clear At least 7Â days |
Nguyen et al., 2007 [57]a | Medical | RCT | 75 | 50.9Â years in the intervention group, 52Â years in the control group | 70 | 23 in the intervention group, 22.6 in the control group | 100Â % | Combination prokinetic therapy (erythromycin and metoclopramide) Significantly higher caloric intake | Erythromycin alone Lower caloric intake | 7Â days |
Desachy et al., 2008 [58]a | Medical and surgical | RCT | 100 | 64 years in the interventional group, 58 years in the control group | 69 | APACHE II is not reported SAPS II: 40 in gradual feeding group, 42 in immediate feeding group | 100 % | Gradual feeding 76 % of optimal calorie intake (1297 ± 331 kcal) | Immediate feeding 95 % of optimal calorie intake (1715 ± 331 kcal) | 120 ± 48 hours (similar in the two groups); 45 patients were followed for maximum of 7 days |
Hsu et al., 2009 [59] | Medical | RCT | 121 | 70 years in the intervention, 67.9 years in the control group | 70.2 | 20.5 in the intervention group, 20.3 in the control group | 100 % | Nasoduodenal feeding group (1658 ± 118 kcal; 27.1 ± 7.6 kcal/kg/day) Protein intake: 1.11 ± 0.31 g/kg/day | Nasogastric feeding group (1426 ± 110 kcal; 23.5 ± 8.8 kcal/kg/day) Protein intake 0.97 ± 0.39 g/kg/day | Mean study period was 11 days |
White et al., 2009 [60] | Medical | RCT | 104 | 50Â years in the intervention group, 54Â years in the control group | 50 | 30 in the intervention group, 24.5 in the control group | 100Â % | Postpyloric feeding (1296Â kcal; 88.5Â % of caloric requirement) Average protein deficit 6.5Â g/day | Gastric feeding (1515Â kcal; 95Â % of caloric requirement) Average protein deficit 3.5Â g/day | Not reported Mean gastric feeding duration was 3.1Â days, mean postpyloric feeding duration was 4.0Â days |
Montejo et al., 2010 [61]a | Medical and surgical | RCT | 329 | 65 years in the intervention group, 60 years in the control group | 65 | 19.4 in the intervention group, 18.9 in the control group | 100 % | High gastric residual volume of 500 ml (diet volume ratio in the first week = 88.2 %) | Low gastric residual volume of 200 ml (diet volume ratio in the first week = 84.5 %) | The duration of enteral nutrition (maximum of 28 days) |
Acosta-Escribano et al., 2010 [62]a | Severe traumatic brain injury | RCT | 104 | 35Â years in the intervention group, 41Â years in the control group | 86.5 | 16 in the intervention group, 18 in the control group | 100Â % | Transpyloric feeding (92Â % of the feeding volume given) | Gastric feeding (84Â % of the feeding volume given) | Not reported |
Arabi et al., 2011 [14] | Medical and surgical | RCT | 240 | 50.3 years in the intervention group, 5.19 years in the control group | 68.3 | 25.2 in the intervention group, 25.3 in the control group | 99.2 % | Permissive under feeding: 59 % of requirement (1066 ± 306 kcal; 13.9 kcal/kg/day) Protein intake 0.61 g/kg/day | Target feeding 71.4 % of requirement (1251 ± 432 kcal; 16.4 kcal/kg/day) Protein intake 0.57 g/kg/day | Duration of enteral feeding or ICU discharge |
Singer et al., 2011 [63] | Medical, surgical and trauma | RCT | 130 | 59 years in the intervention group, 62 years in the control group | 58 | 22.1 in the intervention group, 22.4 in the control group | 100 % | Tight caloric intake according to indirect calorimetry (2086 ± 467 kcal) Protein intake 0.95 g/kg/day | Standard caloric intake at 25 kcal/kg/day (1480 ± 356 kcal) Protein intake 0.68 g/kg/day | Not clear. Till day 14 or discharge from the ICU |
Rice et al., 2011 [15] | Acute respiratory failure | RCT | 200 | 53 years in the intervention group, 54 years in the control group | 44 | 26.9 in both groups | 100 % | Trophic feeding (300 ± 149 kcal; 15.8 ± 11 % of caloric requirement) Protein intake: 0.13 g/kg/day | Full feeding (1418 ± 686 kcal; 74.8 ± 38.5 % of caloric requirement) Protein intake 0.66 g/kg/day | 6 days |
Rice et al., 2012 [16]a | ARDS patients (medical, surgical and trauma) | RCT | 1000 | 52Â years in the intervention and control groups | 51 | APACHE III: 92 in the intervention group, 90 in the control group | 100Â % | Trophic feeding (400Â kcal; 25Â % of estimated non-protein caloric requirement) | Full feeding (1300Â kcal; 80Â % of estimated caloric requirement) | 6Â days |
Huang et al., 2012 [64] | Medical | RCT | 101 | 70.9 years in the intervention group, 68.3 years in the control group | 71 | 21.0 in the intervention group, 19.6 in the control group | 100 % | Nasoduodenal feeding (1575 kcal; 90.4 % of target energy intake). Protein intake 93.2 ± 26.9 % of target | Nasogastric feeding (1343 kcal; 76.2 % of target energy intake) Protein intake 78.6 ± 28.5 % of target | 21 days |
Reignier et al., 2013 [65]a | Medical and surgical | RCT | 449 | 61Â years in the intervention group, 62Â years in the control group | 70 | Baseline SOFA 8 for both groups | 100Â % | Not monitoring residual gastric volume (calorie deficit 319Â kcal) | Monitoring residual gastric volume (calorie deficit 509Â kcal) | Not clear Follow up for 90Â days |
Rugeles et al., 2013 [23] | Medical and surgical | RCT | 80 | 53.3Â years in the intervention group, 55.7Â years in the control group | 58 | 13.9 in the intervention group, 15.1 in the control group | Â | Hyperproteic hypocaloric enteral nutrition as 15Â kcal/kg/day (756Â kcal) Protein intake 1.4Â g/kg/day | Standard nutritional regimen as 25Â kcal/kg/day (921Â kcal) Protein intake 0.76Â g/kg/day | 7Â days |
Peake et al., 2014 [66] | Mechanically ventilated (medical and surgical) | RCT | 112 | 56.4 years in the intervention group, 56.5 years in the control group | 74 | 23 in the intervention group, 22 in the control group | 100 % | Nutritional formula 1.5 kcal/ml (1832 ± 381 kcal; 27.3 ± 7.4 kcal/kg; 96.0 % of requirement) Protein intake 75 % of target | Nutritional formula 1 kcal/ml (1259 ± 428 kcal; 19.0 ± 6.0 kcal/kg; 68.4 % of requirement) Protein intake 79 % of target | 10 days |
Charles et al., 2014 [22] | Surgical/ trauma | RCT | 83 | 50.4 years in the intervention group, 53.4 years in the control group | 71 | 16.6 in the intervention group, 17.3 in the control group | 62.7 % | Hypocaloric feeding: 50 % of estimated requirement as 12.5-15 kcal/kg/day (982 ± 61 kcal; 12.3 ± 0.7 kcal/kg/day) Protein intake 1.1 g/kg/day | Eucaloric feeding 100 % of estimated requirement as 25–30 kcal/kg/day (1338 ± 92 kcal; 17.1 ± 1.1 kcal/kg/day) Protein intake 1.1 g/kg/day | Not clear |
Braunschweig et al., 2015 [67] | Acute lung injury patients (medical and surgical) | RCT | 78 | 52.5 years in the intervention group, 58.6 years in the intervention group | 51.2 | 23.4 in the intervention group, 27.7 in the control group |  | Intensive medical nutrition: >75 % of estimated energy and protein needs by a multifaceted approach (1798 ± 509 kcal; 25.4 ± 6.6 kcal/kg/day; 84.7 % of energy needs) Protein intake 0.95 g/kg/day | Standard nutrition support care (1221 ± 423 kcal; 16.6 ± 5.6 kcal/kg/day; 55.4 % of energy needs) Protein intake 0.68 g/kg/day | Till hospital discharge |
Arabi et al., 2015 [68] | Medical and surgical | RCT | 894 | 50.2 years in the intervention group, 50.9 years in the control group | 64.2 | 21.0 in the intervention and control groups | 96.8 % | Permissive underfeeding 40–60 % of caloric requirements: (835 ± 297 kcal; 46 % of requirement) Protein intake 0.72 g/kg/day | Standard feeding: 70–100 % of caloric requirements (1299 ± 467 kcal; 71 % of requirement) Protein intake 0.73 g/kg/day | Up to 14 days |
Doig et al., 2015 [69]a | Medical and surgical | RCT | 331 | 59 years in the intervention group, 61 years in the control group | 58.6 | 18 in the intervention and control groups | 91 % | Protocolized caloric restriction 20 kcal/h for ≥2 days then caloric intake adjusted depending on serum phosphate | Standard care, mean caloric intake at enrolment 68.5 kcal/h | At least 4 days |