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Table 4 Factors associated with day-60 mortality in univariable and multivariable Cox models

From: Septic shock with no diagnosis at 24 hours: a pragmatic multicenter prospective cohort study

Variables Univariable analysis Multivariable analysisa
HR (95 % CI) P HR (95 % CI) P
Categorization of shock
 EC-SS 1   - -
 Non EC-SS 0.87 (0.65–1.16) 0.34   
Cirrhosis
 No 1   1  
 Yes 2.04 (1.42–2.93) <0.0001 2.45 (1.63–3.69) <0.0001
Cancer
 No 1   1  
 Yes 1.62 (1.15–2.28) 0.006 1.91 (1.32–2.75) <0.001
Chronic respiratory failure
 No 1   1  
 Yes 2.16 (1.30–3.59) 0.003 2.45 (1.41–4.26) 0.002
Age >68 years
 No 1   1  
 Yes 1.47 (1.14–1.91) <0.0001 1.73 (1.30–2.30) <0.0001
SAPS2 > 58
 No 1   1  
 Yes 3.01 (2.28–3.96) <0.0001 1.94 (1.43–2.64) <0.0001
PT ratio <50%
 No 1   1  
 Yes 1.96 (1.50–2.55) <0.0001 1.41 (1.05–1.91) 0.024
Mechanical ventilation
 No 1   1  
 Yes 3.65 (2.33–5.72) <0.0001 2.53 (1.57–4.09) <0.0001
Lactate, per point in mmol/L 1.09 (1.07–1.11) <0.0001 1.06 (1.04–1.09) <0.0001
  1. Patients were categorized as having early-confirmed (i.e., within 24 h of vasopressor initiation) septic shock (EC-SS) or not (non EC-SS). aAdjusted for center. CI confidence interval, HR hazard ratio, PT prothrombin time, SAPS2 simplified acute physiology score 2