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Table 4 Factors associated with day-60 mortality in univariable and multivariable Cox models

From: Septic shock with no diagnosis at 24 hours: a pragmatic multicenter prospective cohort study

Variables

Univariable analysis

Multivariable analysisa

HR (95 % CI)

P

HR (95 % CI)

P

Categorization of shock

 EC-SS

1

 

-

-

 Non EC-SS

0.87 (0.65–1.16)

0.34

  

Cirrhosis

 No

1

 

1

 

 Yes

2.04 (1.42–2.93)

<0.0001

2.45 (1.63–3.69)

<0.0001

Cancer

 No

1

 

1

 

 Yes

1.62 (1.15–2.28)

0.006

1.91 (1.32–2.75)

<0.001

Chronic respiratory failure

 No

1

 

1

 

 Yes

2.16 (1.30–3.59)

0.003

2.45 (1.41–4.26)

0.002

Age >68 years

 No

1

 

1

 

 Yes

1.47 (1.14–1.91)

<0.0001

1.73 (1.30–2.30)

<0.0001

SAPS2 > 58

 No

1

 

1

 

 Yes

3.01 (2.28–3.96)

<0.0001

1.94 (1.43–2.64)

<0.0001

PT ratio <50%

 No

1

 

1

 

 Yes

1.96 (1.50–2.55)

<0.0001

1.41 (1.05–1.91)

0.024

Mechanical ventilation

 No

1

 

1

 

 Yes

3.65 (2.33–5.72)

<0.0001

2.53 (1.57–4.09)

<0.0001

Lactate, per point in mmol/L

1.09 (1.07–1.11)

<0.0001

1.06 (1.04–1.09)

<0.0001

  1. Patients were categorized as having early-confirmed (i.e., within 24 h of vasopressor initiation) septic shock (EC-SS) or not (non EC-SS). aAdjusted for center. CI confidence interval, HR hazard ratio, PT prothrombin time, SAPS2 simplified acute physiology score 2