Table 1 Baseline characteristics of patients admitted to the ICU with suspected septic shock (n = 508) and comparison between patients with early-confirmed septic shocks (EC-SS) and other patients (non EC-SS)
From: Septic shock with no diagnosis at 24 hours: a pragmatic multicenter prospective cohort study
All patients (n = 508) | EC-SS (n = 374) | Non EC-SS (n = 134) | P | |
|---|---|---|---|---|
Age and gender | ||||
Age, years | 68 (59–79) | 67 (58–80) | 68 (61–78) | 0.81 |
Male gender | 297 (58) | 219 (59) | 78 (58) | >0.99 |
Comorbidities | ||||
Chronic respiratory disease | 21 (4) | 17 (5) | 4 (3) | 0.44 |
Chronic heart failure | 34 (7) | 22 (6) | 12 (9) | 0.22 |
Chronic kidney disease | 46 (9) | 33 (9) | 13 (10) | 0.76 |
Cirrhosis | 49 (10) | 35 (9) | 14 (10) | 0.71 |
Recent malignant hemopathy | 34 (7) | 27 (7) | 7 (5) | 0.43 |
Recent cancer | 63 (12) | 43 (11) | 20 (15) | 0.30 |
Diabetes mellitus | 132 (26) | 87 (23) | 45 (34) | 0.019 |
HIV infection | 17 (3) | 11 (3) | 6 (4) | 0.40 |
Obesity | 71 (14) | 54 (14) | 17 (13) | 0.62 |
Cerebrovascular disease | 55 (11) | 37 (10) | 18 (13) | 0.26 |
Immunosuppressive therapy | 54 (11) | 41 (11) | 13 (10) | 0.68 |
Immunosuppression statusa | 132 (26) | 95 (25) | 37 (28) | 0.62 |
No coexisting comorbid conditions | 154 (30) | 119 (32) | 35 (26) | 0.22 |
Clinical data within 24 h of inclusion and antibiotic therapy | ||||
Maximal temperature, °C | 38.2 (37.3–39.0) | 38.4 (37.4 − 39.1) | 37.9 (36.9 − 38.6) | <0.0001 |
Minimal temperature, °C | 36.1 (35.2–37.0) | 36.2 (35.4–37.0) | 36.0 (34.6–36.8) | 0.006 |
Glasgow Coma Scale | 14 (11–15) | 15 (12–15) | 13 (9–15) | 0.002 |
SAPS2 | 58 (47–73) | 58 (45–72) | 59 (50–75) | 0.34 |
Delay admission-inclusion, hours | 1 (0–6) | 2 (0–7) | 1 (0–4) | 0.33 |
Delay inclusion -ATB1, hours | 0 (0–1) | 0 (0–1) | 0 (0–1) | 0.28 |
Delay inclusion -ATB2, hours | 0 (0–2) | 0 (0–2) | 0 (0–2) | 0.59 |
Number of ATB administered at 3 h | 2 (1–2) | 2 (1–2) | 2 (1–2) | 0.09 |
Number of ATB administered at 24 h | 2 (2–3) | 2 (2–3) | 2 (1–3) | 0.050 |
Biological data within 24 h of inclusion | ||||
Leukocyte count, 103.mm−3 | 16.5 (9.9–24.6) | 17.1 (9.8–24.9) | 15.9 (9.9–23.0) | 0.62 |
Platelets count, 103/mm−3 | 156 (85–243) | 156 (81–45) | 155 (92–236) | 0.72 |
C-reactive protein, mg/Lb | 166 (87 − 265) | 178 (110 − 288) | 108 (48–179) | <0.0001 |
Procalcitonin, ng/mLc | 7.6 (1.3–37.9) | 19.6 (3.7–56.5) | 1.6 (0.7–7.8) | <0.0001 |
Serum urea, mmol/L | 14.0 (8.7–21.7) | 13.6 (8.7–20.0) | 16.0 (9.1–24.0) | 0.16 |
Serum creatinine, μmoL/L | 187 (114–296) | 187 (115–275) | 198 (107–347) | 0.13 |
Prothrombin time, % | 58 (41–72) | 58 (42–72) | 56 (38–72) | 0.72 |
Arterial lactate, mmol/L | 3.5 (2.0–7.0) | 3.4 (2.0–6.1) | 3.6 (2.0–10.0) | 0.13 |