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Table 1 Demographic characteristics of the patients and clinical endpoints of selected studies

From: Prehospital fibrinolysis versus primary percutaneous coronary intervention in ST-elevation myocardial infarction: a systematic review and meta-analysis of randomized controlled trials

  STREAM CAPTIM ASSENT-4 PCI
Prehospital FL (n = 944) PPCI (n = 948) Prehospital FL (n = 419) PPCI (n = 421) Prehospital FL (n = 163) PPCI (n = 171)
Demographics
 Age, years 59.7 ± 12.4a 59.6 ± 12.5a 58 (49–69)b 58 (50–68)b 60 (51–69)b
 Age ≥75 years 134 (14.2 %) 121(12.8 %) 42 (10.0 %) 40 (9.5 %) n/a n/a
 Female sex 194 (20.6 %) 208 (21.9 %) 74 (17.5 %) 78 (18.5 %) 19.5 %
 Diabetes 113/934 (12.1 %) 123/939 (13.1 %) 46 (11.1 %) 57 (13.5 %) 13.2 %
 Hypertension 434/930 (46.7 %) 414/932 (44.4 %) 141 (33.9 %) 146 (34.8 %) 43.4 %
 Dyslipidemia    212 (51.1 %) 215 (51.4 %) 35.9 %
 Previous PCI 60/942 (6.4 %) 83/944 (8.8 %) 22 (5.3 %) 18 (4.3 %) 9.4 %
 Previous CABG 2/944 (0.2 %) 3/946 (0.3 %) 0 5 (1.2 %) 1.2 %
 Previous MI 81/940 (8.6 %) 98/947 (10.3 %) 34 (8.2 %) 28 (6.7 %) 11.5 %
 Heart rate 74.9 ± 18.4 75.5 ± 18.1 76 (64–84) 75 (66–88) n/a n/a
 Systolic blood pressure, mmHg 135.0 ± 22.7 135.9 ± 14.9 125 (110–140) 128 (111–140) n/a n/a
 Anterior MI 453/942 (48.1 %) 431/946 (45.6 %) 166 (40.2 %) 178 (42.7 %) 45.8 %
Median time delay (IQR), minutes
 Symptom onset to randomization, minutes 91 (68–132) 92 (65–132) 107 (76–158) 108 (76–162) 105 (75–172) 105 (70–160)
 Symptom onset to start of reperfusion treatment: thrombolysis or balloon inflation 100 (75–143) 178 (135–230) 130 (95–180) 190 (149–255) 125 (90–185) 203 (154–258)
 PCI 736/915 (80.4 %) 838/933 (89.9 %) 295 (70.4 %) 364 (86.5 %) n/a n/a
Endpoints
 Primary composite endpointc 116/939 (12.4 %) 135/943 (14.3 %) 34 (8.2 %) 26 (6.2 %) 31/161 (19.3 %) 23/165 (13.9 %)
 Death 43/939 (4.6 %) 42/946 (4.4 %) 16 (3.8 %) 20 (4.8 %) 5/163 (3.1 %) 7/171 (4.1 %)
 Stroke 15/939 (1.6 %) 5/946 (0.5 %) 4 (1.0 %) 0 n/a n/a
 Reinfarction 23/938 (2.5 %) 21/944 (2.2 %) 15 (3.7 %) 7 (1.7 %) n/a n/a
 Severe hemorrhage 70/939 (7.5 %) 47/946 (5 %) 2 (0.5 %) 8 (2.0 %) 13/163 (8.0 %) 11/171 (6.4 %)
  1. Abbreviations: CABG Coronary artery bypass graft, MI Myocardial infarction, n/a Not available, PCI Percutaneous coronary intervention, PPCI Primary percutaneous coronary intervention, ASSENT-4 PCI Assessment of the Safety and Efficacy of a New Treatment Strategy with Percutaneous Coronary Intervention study, CAPTIM Comparison of primary Angioplasty and Pre-hospital fibrinolysis In acute Myocardial infarction trial, STREAM Strategic Reperfusion Early after Myocardial Infarction trial
  2. aMean
  3. bMedian (IQR)
  4. cThe primary composite endpoint was a composite of “death, shock, congestive heart failure or reinfarction at 30 days” for STREAM; “death, non-fatal reinfarction, and non-fatal disabling stroke in 30 days” for CAPTIM; and “mortality, shock, or congestive heart failure within 90 days” for ASSENT-4 PCI