Skip to main content

Table 1 Demographic characteristics of the patients and clinical endpoints of selected studies

From: Prehospital fibrinolysis versus primary percutaneous coronary intervention in ST-elevation myocardial infarction: a systematic review and meta-analysis of randomized controlled trials

 

STREAM

CAPTIM

ASSENT-4 PCI

Prehospital FL (n = 944)

PPCI (n = 948)

Prehospital FL (n = 419)

PPCI (n = 421)

Prehospital FL (n = 163)

PPCI (n = 171)

Demographics

 Age, years

59.7 ± 12.4a

59.6 ± 12.5a

58 (49–69)b

58 (50–68)b

60 (51–69)b

 Age ≥75 years

134 (14.2 %)

121(12.8 %)

42 (10.0 %)

40 (9.5 %)

n/a

n/a

 Female sex

194 (20.6 %)

208 (21.9 %)

74 (17.5 %)

78 (18.5 %)

19.5 %

 Diabetes

113/934 (12.1 %)

123/939 (13.1 %)

46 (11.1 %)

57 (13.5 %)

13.2 %

 Hypertension

434/930 (46.7 %)

414/932 (44.4 %)

141 (33.9 %)

146 (34.8 %)

43.4 %

 Dyslipidemia

  

212 (51.1 %)

215 (51.4 %)

35.9 %

 Previous PCI

60/942 (6.4 %)

83/944 (8.8 %)

22 (5.3 %)

18 (4.3 %)

9.4 %

 Previous CABG

2/944 (0.2 %)

3/946 (0.3 %)

0

5 (1.2 %)

1.2 %

 Previous MI

81/940 (8.6 %)

98/947 (10.3 %)

34 (8.2 %)

28 (6.7 %)

11.5 %

 Heart rate

74.9 ± 18.4

75.5 ± 18.1

76 (64–84)

75 (66–88)

n/a

n/a

 Systolic blood pressure, mmHg

135.0 ± 22.7

135.9 ± 14.9

125 (110–140)

128 (111–140)

n/a

n/a

 Anterior MI

453/942 (48.1 %)

431/946 (45.6 %)

166 (40.2 %)

178 (42.7 %)

45.8 %

Median time delay (IQR), minutes

 Symptom onset to randomization, minutes

91 (68–132)

92 (65–132)

107 (76–158)

108 (76–162)

105 (75–172)

105 (70–160)

 Symptom onset to start of reperfusion treatment: thrombolysis or balloon inflation

100 (75–143)

178 (135–230)

130 (95–180)

190 (149–255)

125 (90–185)

203 (154–258)

 PCI

736/915 (80.4 %)

838/933 (89.9 %)

295 (70.4 %)

364 (86.5 %)

n/a

n/a

Endpoints

 Primary composite endpointc

116/939 (12.4 %)

135/943 (14.3 %)

34 (8.2 %)

26 (6.2 %)

31/161 (19.3 %)

23/165 (13.9 %)

 Death

43/939 (4.6 %)

42/946 (4.4 %)

16 (3.8 %)

20 (4.8 %)

5/163 (3.1 %)

7/171 (4.1 %)

 Stroke

15/939 (1.6 %)

5/946 (0.5 %)

4 (1.0 %)

0

n/a

n/a

 Reinfarction

23/938 (2.5 %)

21/944 (2.2 %)

15 (3.7 %)

7 (1.7 %)

n/a

n/a

 Severe hemorrhage

70/939 (7.5 %)

47/946 (5 %)

2 (0.5 %)

8 (2.0 %)

13/163 (8.0 %)

11/171 (6.4 %)

  1. Abbreviations: CABG Coronary artery bypass graft, MI Myocardial infarction, n/a Not available, PCI Percutaneous coronary intervention, PPCI Primary percutaneous coronary intervention, ASSENT-4 PCI Assessment of the Safety and Efficacy of a New Treatment Strategy with Percutaneous Coronary Intervention study, CAPTIM Comparison of primary Angioplasty and Pre-hospital fibrinolysis In acute Myocardial infarction trial, STREAM Strategic Reperfusion Early after Myocardial Infarction trial
  2. aMean
  3. bMedian (IQR)
  4. cThe primary composite endpoint was a composite of “death, shock, congestive heart failure or reinfarction at 30 days” for STREAM; “death, non-fatal reinfarction, and non-fatal disabling stroke in 30 days” for CAPTIM; and “mortality, shock, or congestive heart failure within 90 days” for ASSENT-4 PCI
Back to article page

Critical Care

ISSN: 1364-8535