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Table 1 Characteristics of the study population, according to ICU survival and neurological outcome at hospital discharge

From: The impact of extracerebral organ failure on outcome of patients after cardiac arrest: an observational study from the ICON database

  All patients (n = 469) Survivors (n = 247) Non-survivors (n = 210) Favorable neurological outcome (n = 97) Unfavorable neurological outcome (n = 357)
Age, years 66 (52–77) 65 (52–75) 68 (52–78) 67 (53–75) 66 (52–77)
Male, n (%) 282 (61) 149 (61) 126 (61) 60 (62) 222 (60)
Weight, kg 75 (65–87) 75 (66–90) 71 (61–83) 75 (65–90) 74 (65–85)
OHCA, n (%) 250 (53) 120 (49) 124 (59) 34 (35) 216 (58)
IHCA, n (%) 219 (47) 127 (51) 86 (41) 63 (65) 156 (42)
No co-morbidities, n (%) 209 (44) 101 (41) 108 (51) 49 (51) 163 (44)
COPD/asthma, n (%) 65 (14) 39 (16) 26 (12) 17 (17) 51 (14)
Heart failure, n (%) 72 (15) 30 (12) 42 (20) 10 (10) 62 (17)
Diabetes, n (%) 45 (10) 20 (8) 25 (12) 12 (12) 33 (9)
Cancer, n (%) 38 (8) 18 (7) 20 (10) 10 (10) 28 (8)
Chemotherapy, n (%) 9 (2) 4 (2) 5 (2) 1 (1) 8 (2)
Liver cirrhosis, n (%) 14 (3) 1 (1) 13 (6) 1 (1) 13 (3)
Chronic renal failure, n (%) 50 (11) 21 (9) 29 (14) 10 (10) 40 (11)
HIV, n (%) 1 (0) 1 (1) 1 (1)
Corticosteroids, n (%) 14 (3) 6 (2) 8 (4) 1 (1) 13 (3)
Medical admission, n (%) 373 (83) 189 (91) 184 (89) 70 (74) 303 (84)
SAPS II score on admission 60 (46–75) 53 (39–64) 71 (57–81)* 38 (29–49) 65(54–79)*
SOFA score on admission 10 (7–13) 8 (6–11) 12 (9–14)* 6 (3–8) 11(8–13)*
Infections      
 Infection on admission, n (%) 112 (24) 60 (24) 52 (25) 20 (21) 92 (25)
 Infection any time, n (%) 200 (43) 120 (49) 80 (38) 41 (41) 159 (43)
 Septic shock on admission, n (%) 75 (16) 40 (16) 35 (17) 11 (11) 64 (17)
 Septic shock any time, n (%) 133 (28) 74 (30) 59 (28) 20 (21) 113 (30)
Vasopressors on admission, n (%) 262 (57) 124 (50) 138 (66)* 42 (43) 220 (62)*
Mechanical ventilation on admission, n (%) 408 (87) 205 (83) 203 (97) 67 (69) 341 (92)*
Mechanical ventilation any time, n (%) 425 (91) 211 (85) 204 (97) 71 (73) 354 (95)*
Hemodialysis/CRRT on admission, n (%) 38 (8) 19 (8) 19 (9) 4 (4) 34 (9)
Hemodialysis/CRRT any time, n (%) 103 (23) 59 (24) 44 (21) 17 (17) 86 (23)
MAP maximum on first day, mmHg 99 (87–112) 100 (89–113) 97 (85–111) 100 (88–113) 98 (87–112)
MAP minimum on first day, mmHg 61 (50–70) 63 (55–71) 56 (45–68) 63 (55–79) 60 (49–70)*
pH maximum on first day, mmHg 7.40 (7.30–7.45) 7.41 (7.35–7.46) 7.37 (7.23–7.44)* 7.42 (7.36–7.47) 7.39 (7.28–7.45)*
pH minimum on first day, mmHg 7.25 (7.11–7.35) 7.29 (7.19–7.36) 7.18 (7.05–7.29)* 7.32 (7.23–7.38) 7.23 (7.10–7.33)*
PaCO2 maximum on first day, mmHg 45 (37–57) 44 (36–55) 46 (37–60) 45 (37–53) 45 (36–60)
PaCO2 minimum on first day, mmHg 34 (28–40) 34 (28–40) 33 (27–39) 35 (29–40) 33 (28–40)
PaO2 maximum on first day, mmHg 144 (98–229) 135 (94–197) 149 (101–265) 141 (95–190) 145 (99–234)
PaO2 minimum on first day, mmHg 77 (61–98) 77 (64–94) 75 (57–105) 78 (66–90) 76 (60–100)
PaO2/FiO2 maximum on first day 232 (144–344) 232 (151–337) 233 (132–361) 270 (161–374) 227 (143–343)*
PaO2/FiO2 minimum on first day 195 (132–288) 200 (149–294) 186 (120–285)* 218 (165–300) 192 (124–285)*
Lactate maximum on first day, mmol/L 3.6 (2.0–7.6) 2.6 (1.5–5.5) 5.8 (2.5–10.5)* 2.1 (1.2–5.5) 4.30 (2.3–8)*
ICU stay, days 4 (2–8) 5 (3–10) 3 (1–6)* 4 (2–6) 4 (1–8)
Hospital stay, days 8 (2–20) 17 (8–31) 3 (1–6)* 15 (8–22) 5 (2–16)*
Limitation of care, n (%) 170 (36) 40 (16) 126 (61)* 11 (11) 159 (44)*
ICU mortality, n (%) 210 (45) 210 (100)* 210 (59)
Hospital mortality, n (%) 247 (54) 37 (15) 210 (100)* 11 (11) 236 (67)*
  1. Values are given as median (interquartile range) unless otherwise stated
  2. Missing values: 12 for mortality; 5 for sex; 36 for weight; 23 for source of admission; 15 for vasopressors on admission; 15 for ICU stay, 16 for hospital stay
  3. *p < 0.05, survivors versus non-survivors; favorable outcome versus unfavorable outcome
  4. COPD chronic obstructive pulmonary disease, CRRT continuous renal replacement therapy, FiO 2 fraction of inspired oxygen, HIV human immunodeficiency virus, ICU intensive care unit, IHCA in-hospital cardiac arrest, MAP mean arterial pressure, OHCA out-of-hospital cardiac arrest, PaO 2 partial pressure of oxygen, PaCO 2 partial pressure of carbon dioxide, SAPS Simplified Acute Physiology Score, SOFA Sequential Organ Failure Assessment