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Fig. 5 | Critical Care

Fig. 5

From: Subglottic secretion suction for preventing ventilator-associated pneumonia: an updated meta-analysis and trial sequential analysis

Fig. 5

Trial sequential analysis for sensitivity analysis of incidence of ventilator-associated pneumonia. In (ah) TSA plots, all Z curves have crossed the trial sequential monitoring boundary for benefit. a Trial sequential analysis in 12 appropriate randomized trials with control arm event proportion of 20.5 %, relative risk reduction of 20 %, α of 5 % (two sided), β of 20 %, and I 2 = 7 %. The required information size was calculated as 2811. b Trial sequential analysis in five appropriate allocation concealment trials with control arm event proportion of 14.2 %, relative risk reduction of 20 %, α of 5 % (two sided), β of 20 %, and I 2 = 0 %. The required information size was calculated as 4339. c Trial sequential analysis in eight appropriate assessment blinded trials with control arm event proportion of 24.5 %, relative risk reduction of 20 %, α of 5 % (two sided), β of 20 %, and I 2 = 11 %. The required information size was calculated as 2248. d Trial sequential analysis in 10 trials including over 100 participants with control arm event proportion of 18.0 %, relative risk reduction of 20 %, α of 5 % (two sided), β of 20 %, and I 2 = 0 %. The required information size was calculated as 3289. e Trial sequential analysis in nine intermittent suction trials with control arm event proportion of 26.7 %, relative risk reduction of 20 %, α of 5 % (two sided), β of 20 %, and I 2 = 22 %. The required information size was calculated as 2010. f Trial sequential analysis in 11 continuous suction trials with control arm event proportion of 22.3 %, relative risk reduction of 20 %, α of 5 % (two sided), β of 20 %, and I 2 = 22 %. The required information size was calculated as 2532. g Trial sequential analysis in 13 trials with control arm event proportion of 23.0 %, relative risk reduction of 20 %, α of 5 % (two sided), β of 20 %, and I 2 = 0 %. The required information size was calculated as 2436. h Trial sequential analysis in 16 trials excluding multiple manipulations studies with control arm event proportion of 16.1 %, relative risk reduction of 20 %, α of 5 % (two sided), β of 20 %, and I 2 = 0 %. The required information size was calculated as 2547. SSS, subglottic secretion suctioning

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