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Table 3 Multivariable logistic regression analysis evaluating the association between bioavailable estradiol and hospital mortality

From: Bioavailable estradiol concentrations are elevated and predict mortality in septic patients: a prospective cohort study

Dependent variable Independent variables Odds ratioa (95 % CI) p Value
Hospital mortality Bioavailable estradiol ≥ median 4.27 (1.65–11.06) 0.003
Age in years 1.04 (1.01–1.07) 0.009
Charlson index ≥ median 4.15 (1.53–11.27) 0.005
  1. The final parsimonious multivariable model included age in years and Charlson comorbidity index dichotomized by the median value (3). This model had good discrimination (c-statistic = 0.73) and acceptable calibration (Hosmer-Lemeshow χ2 = 13.4, p = 0.10)
  2. aOdds ratios refer to the change in likelihood of hospital mortality for patients with bioavailable estradiol concentration ≥211 pM, a 1-year increase in age, and a Charlson comorbidity index ≥3, all after adjustment for the other two variables