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Table 4 Population pharmacokinetic mean, median and SD parameters of meropenem obtained using Pmetrics

From: Cerebrospinal fluid penetration of meropenem in neurocritical care patients with proven or suspected ventriculitis: a prospective observational study

 

Mean

Median

SD

CL, L/h

16.045

15.025

±5.575

Vc, L

10.949

13.736

±4.491

K cp, L−1

1.562

1.248

±1.031

K pc, L−1

1.686

1.898

±1.206

K cb, L−1

0.052

0.026

±0.049

K bc, L−1

0.092

0.054

±0.097

VCSF, L

82.932

93.902

±18.802

  1. Abbreviations: CL Clearance, V c Volume of distribution of the central compartment, V CSF Volume of distribution of the cerebrospinal fluid compartment, K cp, K pc, K bc, K cb Linear transfer rate constants
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Critical Care

ISSN: 1364-8535