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Table 4 Population pharmacokinetic mean, median and SD parameters of meropenem obtained using Pmetrics

From: Cerebrospinal fluid penetration of meropenem in neurocritical care patients with proven or suspected ventriculitis: a prospective observational study

  Mean Median SD
CL, L/h 16.045 15.025 ±5.575
Vc, L 10.949 13.736 ±4.491
K cp, L−1 1.562 1.248 ±1.031
K pc, L−1 1.686 1.898 ±1.206
K cb, L−1 0.052 0.026 ±0.049
K bc, L−1 0.092 0.054 ±0.097
VCSF, L 82.932 93.902 ±18.802
  1. Abbreviations: CL Clearance, V c Volume of distribution of the central compartment, V CSF Volume of distribution of the cerebrospinal fluid compartment, K cp, K pc, K bc, K cb Linear transfer rate constants