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Table 3 Pharmacokinetic properties of meropenem in serum and cerebrospinal fluid

From: Cerebrospinal fluid penetration of meropenem in neurocritical care patients with proven or suspected ventriculitis: a prospective observational study

Patient number

CL (L/h)

Vc (L)

t 1/2 (h)

AUC0–24 serum (mg∙h/L)

AUC0–24 CSF (mg∙h/L)

CSF/serum ratio

t 1/2cb (h)

t 1/2bc (h)

1

7.63

6.45

0.59

768.63

85.53

0.11

3.30

4.62

2

17.88

14.45

0.56

327.09

53.00

0.16

17.33

9.90

3

8.62

14.95

1.20

428.94

48.59

0.11

4.62

3.47

4

20.38

5.05

0.17

300.14

19.37

0.06

13.86

17.33

5

22.87

14.95

0.45

237.60

8.93

0.04

17.33

2.57

6

14.89

5.05

0.24

401.45

18.63

0.05

34.66

69.31

7

23.37

14.95

0.44

258.79

15.02

0.06

34.66

5.78

8

7.88

5.05

0.44

760.20

79.10

0.10

8.66

9.90

9

17.13

14.95

0.60

280.81

26.56

0.09

23.10

17.33

10

11.88

13.75

0.80

489.44

27.25

0.06

69.31

34.66

11

20.63

12.75

0.43

287.15

15.59

0.05

34.66

17.33

12

29.87

9.95

0.23

112.95

10.56

0.09

11.55

9.90

13

15.07

5.05

0.23

234.65

22.10

0.09

23.10

69.31

14

9.63

14.95

1.08

569.59

48.90

0.09

13.86

5.78

15

14.88

5.05

0.24

413.23

25.62

0.06

34.66

69.31

16

17.13

14.95

0.60

337.21

30.99

0.09

23.10

17.33

17

14.98

5.08

0.24

415.22

17.31

0.04

34.66

69.31

18

10.63

5.05

0.33

563.84

42.95

0.08

5.78

8.66

19

13.12

14.95

0.79

394.45

33.99

0.09

34.66

13.86

20

17.13

14.95

0.60

350.22

33.71

0.10

23.10

17.33

21

18.88

14.15

0.52

242.60

7.44

0.03

17.33

1.73

Median

15.07

13.75

0.63

350.22

26.56

0.09

23.10

13.86

Minimum

7.63

5.05

0.17

112.95

7.44

0.03

3.30

1.73

Maximum

29.87

14.95

1.20

768.63

85.53

0.16

69.31

69.31

  1. Abbreviations: CSF Cerebrospinal fluid, CL Median clearance, t 1/2 Median half-life, V c Median volume of distribution of the central compartment, AUC 0–24 Daily average area under the curve, CSF/serum ratio Cerebrospinal fluid penetration, t 1/2cb Median absorption half-life into cerebrospinal fluid, t 1/2bc Median elimination half-life of cerebrospinal fluid
  2. Individual pharmacokinetic results in serum and CSF obtained using Pmetrics