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Table 2 Observed meropenem concentrations in serum and cerebrospinal fluid

From: Cerebrospinal fluid penetration of meropenem in neurocritical care patients with proven or suspected ventriculitis: a prospective observational study

  

Meropenem dosing 1000 mg

Meropenem dosing 2000 mg

Patient number

CrCL (ml/minute)

Cmin (mg/L)

Cmax (mg/L)

Ctrough (mg/L)

Cafter 4h (mg/L)

Cmin (mg/L)

Cmax (mg/L)

Ctrough (mg/L)

Cafter 4h (mg/L)

1

60.7

3.80

N/A

2.00

N/A

10.90

48.60

3.00

4.00

2

156.8

6.90

11.00

N/A

N/A

4.60

26.35

2.75

2.60

3

83.8

4.80

24.10

2.60

1.90

13.80

45.30

2.25

3.45

4

162.9

N/A

N/A

N/A

N/A

1.10

16.40

0.60

0.60

5

217.6

<0.5

5.80

N/A

N/A

2.90

19.40

0.31

0.53

6

124.5

N/A

N/A

N/A

N/A

0.86

19.20

0.76

0.86

7

120.1

N/A

N/A

N/A

N/A

<0.5

15.20

0.43

0.78

8

73.1

N/A

N/A

N/A

N/A

11.00

64.80

3.35

3.00

9

92.1

0.81

12.30

1.08

0.97

3.05

19.65

1.40

1.97

10

96.3

N/A

N/A

N/A

N/A

1.31

33.30

1.62

1.04

11

142.9

N/A

12.82

N/A

1.14

1.02

19.33

0.62

0.74

12

174.1

0,62

5.62

0.39

0.32

N/A

N/A

N/A

N/A

13

100.3

1.38

10.65

1.47

1.15

0.79

19.80

0.87

0.80

14

96.2

N/A

N/A

N/A

N/A

9.83

32.94

2.27

2.19

15

108.8

N/A

N/A

N/A

N/A

1.13

17.51

1.18

0.88

16

125.0

N/A

N/A

N/A

N/A

2.99

27.01

0.92

1.17

17

144.7

N/A

N/A

N/A

N/A

2.44

18.15

0.74

0.58

18

90.5

N/A

20.10

N/A

2.28

7.63

33.80

2.39

1.84

19

131.3

2.50

17.47

0.89

0.83

6.22

26.94

1.79

1.82

20

174.6

N/A

N/A

N/A

N/A

2.63

23.23

1.52

1.58

21

122.5

1.69

10.57

<0.2

0.25

3.65

16.74

0.31

0.44

Median

122.5

1.69

11.65

1.08

1.05

2.95

21.51

1.29

1.10

Minimum

60.7

<0.5

4.40

<0.2

<0.2

<0.5

10.70

<0.2

0.24

Maximum

217.6

7.10

26.60

3.10

2.80

31.40

69.00

4.10

6.20

  1. Abbreviations: C min Median observed serum trough concentration, C max Median observed serum peak concentration, C trough Median observed cerebrospinal fluid concentration at serum trough concentration, C after 4h Median observed cerebrospinal fluid concentration 4 h after serum trough concentration, N/A Not available (patient with only meropenem 1000 mg or only 2000 mg intravenously every 8 h), CrCL Estimated creatinine clearance (calculated using the Cockcroft-Gault equation [16])
  2. Observed meropenem concentrations after 1000 mg or 2000 mg intravenously every 8 h (4-h infusion)
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