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Table 2 Observed meropenem concentrations in serum and cerebrospinal fluid

From: Cerebrospinal fluid penetration of meropenem in neurocritical care patients with proven or suspected ventriculitis: a prospective observational study

   Meropenem dosing 1000 mg Meropenem dosing 2000 mg
Patient number CrCL (ml/minute) Cmin (mg/L) Cmax (mg/L) Ctrough (mg/L) Cafter 4h (mg/L) Cmin (mg/L) Cmax (mg/L) Ctrough (mg/L) Cafter 4h (mg/L)
1 60.7 3.80 N/A 2.00 N/A 10.90 48.60 3.00 4.00
2 156.8 6.90 11.00 N/A N/A 4.60 26.35 2.75 2.60
3 83.8 4.80 24.10 2.60 1.90 13.80 45.30 2.25 3.45
4 162.9 N/A N/A N/A N/A 1.10 16.40 0.60 0.60
5 217.6 <0.5 5.80 N/A N/A 2.90 19.40 0.31 0.53
6 124.5 N/A N/A N/A N/A 0.86 19.20 0.76 0.86
7 120.1 N/A N/A N/A N/A <0.5 15.20 0.43 0.78
8 73.1 N/A N/A N/A N/A 11.00 64.80 3.35 3.00
9 92.1 0.81 12.30 1.08 0.97 3.05 19.65 1.40 1.97
10 96.3 N/A N/A N/A N/A 1.31 33.30 1.62 1.04
11 142.9 N/A 12.82 N/A 1.14 1.02 19.33 0.62 0.74
12 174.1 0,62 5.62 0.39 0.32 N/A N/A N/A N/A
13 100.3 1.38 10.65 1.47 1.15 0.79 19.80 0.87 0.80
14 96.2 N/A N/A N/A N/A 9.83 32.94 2.27 2.19
15 108.8 N/A N/A N/A N/A 1.13 17.51 1.18 0.88
16 125.0 N/A N/A N/A N/A 2.99 27.01 0.92 1.17
17 144.7 N/A N/A N/A N/A 2.44 18.15 0.74 0.58
18 90.5 N/A 20.10 N/A 2.28 7.63 33.80 2.39 1.84
19 131.3 2.50 17.47 0.89 0.83 6.22 26.94 1.79 1.82
20 174.6 N/A N/A N/A N/A 2.63 23.23 1.52 1.58
21 122.5 1.69 10.57 <0.2 0.25 3.65 16.74 0.31 0.44
Median 122.5 1.69 11.65 1.08 1.05 2.95 21.51 1.29 1.10
Minimum 60.7 <0.5 4.40 <0.2 <0.2 <0.5 10.70 <0.2 0.24
Maximum 217.6 7.10 26.60 3.10 2.80 31.40 69.00 4.10 6.20
  1. Abbreviations: C min Median observed serum trough concentration, C max Median observed serum peak concentration, C trough Median observed cerebrospinal fluid concentration at serum trough concentration, C after 4h Median observed cerebrospinal fluid concentration 4 h after serum trough concentration, N/A Not available (patient with only meropenem 1000 mg or only 2000 mg intravenously every 8 h), CrCL Estimated creatinine clearance (calculated using the Cockcroft-Gault equation [16])
  2. Observed meropenem concentrations after 1000 mg or 2000 mg intravenously every 8 h (4-h infusion)