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Table 2 Cox proportional hazards regression model analysis for prognostic factors of emergency ECMO use

From: The modified SAVE score: predicting survival using urgent veno-arterial extracorporeal membrane oxygenation within 24 hours of arrival at the emergency department

Variables Univariate analysis Multivariate analysis
Hazard ratio (95 % CI) p value Hazard ratio (95 % CI) p value
SAVE score 0.92 (0.90-0.95) <0.001 0.92 (0.88–0.96) 0.001
SOFA score 1.11 (1.04–1.17) 0.001 0.96 (0.89–1.05) 0.37
Age (yr) 1.02 (1.01–1.03) <0.001 NEa  
OHCA 1.77 (1.19–2.64) 0.005 1.13 (0.69–1.86) 0.62
Laboratory findings
 PaCO2 (mmHg) 1.02 (1.01–1.03) 0.001 1.00 (0.99–1.01) 0.93
 HCO3 - (mmol/L) 0.94 (0.91–0.97) 0.001 NEa  
 Lactate (mg/dL) 1.01 (1.01–1.01) <0.001 1.01 (1.01–1.01) <0.001
 Platelet (x103/μL) 1.00 (0.99–1.00) 0.007 1.00 (1.00–1.00) 0.11
 pH 0.07 (0.02–0.21) <0.001 NEb  
  1. CI confidence interval, ECMO extracorporeal membrane oxygenation, IHCA in-hospital cardiac arrest, OHCA out-of-hospital cardiac arrest, SAVE score Survival After Veno-arterial ECMO score, SOFA score Sequential Organ Failure Assessment score,
  2. aNot entered into the multivariate analysis because age and HCO3 - are involved in SAVE score
  3. bNot entered into the multivariate analysis because of pH and lactate with high collinearity