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Table 4 Subgroup analysis of the risk of death in the hydrocortisone and placebo groups at days 28 and 60

From: Hydrocortisone treatment in early sepsis-associated acute respiratory distress syndrome: results of a randomized controlled trial

  Day 28 Day 60
Subgroup Hydrocortisone (n = 98) Placebo (n = 99) Relative risk with hydrocortisone (95 % CI) p Value Hydrocortisone (n = 98) Placebo (n = 99) Relative risk with hydrocortisone (95 % CI) p Value
Age
 Age ≤65 years, n/total (%) 12/50 (24.0) 16/50 (32.0) 0.75 (0.40–1.42) 0.50 18/50 (36.0) 19/50 (38.0) 0.95 (0.57–1.58) 1.00
 Age >65 years, n/total (%) 10/48 (20.8) 11/49 (22.5) 0.93 (0.43–1.98) 1.00 16/48 (33.3) 21/49 (42.9) 0.78 (0.47–1.3) 0.40
APACHE II score
 APACHE II score <25, n/total (%) 8/61 (13.1) 14/65 (21.5) 0.61 (0.27–1.35) 0.25 16/61 (26.2) 22/65 (33.8) 0.61 (0.27–1.35) 0.44
 APACHE II score ≥ 25, n/total (%) 14/37 (37.8) 13/34 (38.2) 0.99 (0.55–1.79) 1.00 18/37 (48.7) 18/34 (52.9) 0.92 (0.58–1.45) 0.81
Lung injury score
 Lung injury score < 2.5, n/total (%) 11/54 (20.4) 13/58 (22.4) 0.91 (0.45–1.85) 0.82 16/54 (29.6) 17/58 (29.3) 1.01 (0.60–1.79) 1.00
 Lung injury score ≥ 2.5, n/total (%) 11/44 (25) 13/40 (32.5) 0.77 (0.39–0.52) 0.48 18/44 (40.9) 22/40 (55.0) 0.74 (0.47–1.17) 0.27
Sepsis severity
 Severe sepsis without shock, n/total (%) 3/20 (15.0) 3/23 (13.0) 1.15 (0.26–5.07) 1.00 4/20 (20.0) 5/23 (21.7) 0.92 (0.29–2.97) 1.00
 Vasopressor dependent shock, n/total (%) 19/78 (24.4) 24/76 (31.6) 0.77 (0.46–1.29) 0.37 30/78 (38.5) 35/76 (46.1) 0.84 (0.58–1.21) 0.41
ARDS severity
 Mild ARDS, n/total (%) 5/30 (16.7) 7/32 (21.9) 0.76 (0.27–2.14) 0.75 9/30 (30.0) 10/32 (31.3) 0.96 (0.45–2.03) 1.00
 Moderate to severe ARDS, n/total (%) 17/68 (25.0) 20/67 (29.9) 0.84 (0.48–1.45) 0.57 25/68 (36.8) 30/67 (44.8) 0.82 (0.55–1.24) 0.38
Source of infection
 Pneumonia, n/total (%) 11/49 (22.5) 13/51 (25.5) 0.88 (0.44–1.77) 0.82 18/49 (36.7) 19/51 (37.3) 0.99 (0.59–1.64) 1.00
 Others, n/total (%) 1/10 (10.0) 6/18 (33.3) 0.30 (0.04–2.15) 0.36 1/10 (10.0) 7/18 (38.9) 0.26 (0.04–1.80) 0.19
Number of comorbidities
  ≤ 2 comorbidities, n/total (%) 18/67 (26.9) 22/77 (28.6) 0.94 (0.55–1.60) 0.85 25/67 (37.3) 30/77 (39.0) 0.96 (0.63–1.45) 0.87
  ≥ 3 comorbidities, n/total (%) 4/31 (12.9) 5/22 (22.7) 0.57 (0.17–1.88) 0.46 9/31 (29.0) 10/2 (45.5) 0.64 (0.31–1.31) 0.26
  1. APACHE II Acute Physiology and Chronic Health Evaluation II, ARDS Acute respiratory distress syndrome