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Table 3 Univariable and multivariable survival models for time to organ support removal and overall survival on day 28

From: Hydrocortisone treatment in early sepsis-associated acute respiratory distress syndrome: results of a randomized controlled trial

Covariate at study entry Time to vital organ support removal Day 28 survival
HR
(95 % CI)
p Value HR
(95 % CI)
p Value
Univariable models
 Hydrocortisone vs. placebo 1.35 (0.93–1.92) 0.11 0.82 (0.47–1.43) 0.49
 APACHE II score: <25 vs. ≥25 1.46 (0.97–2.18) 0.066 0.39 (0.22–0.69) 0.0011
 Lung Injury Score: <2.5 vs. ≥2.5 1.57 (1.08–2.30) 0.019 0.71 (0.40–1.24) 0.23
 Vasopressor-dependent shock: absent vs. present 1.63 (1.09–2.45) 0.018 0.46 (0.19–1.07) 0.071
 ARDS severity: mild vs. moderate to severe 0.79 (0.54–1.16) 0.23 1.54 (0.81–2.96) 0.19
 Number of comorbidities: ≤2 vs. >2 0.95 (0.64–1.40) 0.79 1.25 (0.71–2.19) 0.44
 Source of infection: pneumonia vs. extrapulmonary source 1.09 (0.64–1.85) 0.75 0.90 (0.51–1.58) 0.71
 Age: ≤65 years vs. >65 years 1.40 (0.97–2.02) 0.071 1.33 (0.76–2.35) 0.32
 Diabetes mellitus: no vs. yes 0.95 (0.64–1.40) 0.79 1.66 (0.84–3.28) 0.18
 Hyperglycemia: no vs. yes 0.97 (0.66–1.42) 0.8 1.37 (0.67–2.80) 0.45
Multivariable models
 Hydrocortisone vs. placebo 1.35 (0.93–1.96) 0.107 0.80 (0.46–1.41) 0.44
 APACHE II score: <25 vs. ≥25 Not included in multivariable model 0.42 (0.24–0.75) 0.003
 Vasopressor-dependent shock: absent vs. present 1.562 (1.04–2.35) 0.032 0.55 (0.23–1.29) 0.17a
 Lung Injury Score: <2.5 vs. ≥2.5 1.633 (1.11–2.4) 0.012 Not included in multivariable model
  1. APACHE II Acute Physiology and Chronic Health Evaluation II, ARDS Acute respiratory distress syndrome
  2. Multivariable survival models for time to survival on day 60 were significant for APACHE II score (HR 0.56, 95 % CI 0.35–0.89; p = 0.015) and Lung Injury Score (HR 0.62, 95 % CI 0.39–0.99; p = 0.045), and they showed a nonsignificant favorable trend for hydrocortisone vs. placebo (HR 0.81, 95 % CI 0.51–1.28; p = 0.37)
  3. aThis variable was included because it was significant in the day 60 survival model