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Fig. 3 | Critical Care

Fig. 3

From: Hydrocortisone treatment in early sepsis-associated acute respiratory distress syndrome: results of a randomized controlled trial

Fig. 3

a Kaplan-Meier estimate of time to removal of organ support by treatment arm after adjustment by Cox regression analysis for Acute Physiology and Chronic Health Evaluation II (APACHE II) score and Lung Injury Score. Continuous line corresponds to the placebo group, and dashed line corresponds to the hydrocortisone group. b Kaplan-Meier curve illustrates the probability of survival at 60 days based on APACHE II score <25 vs. ≥25. Continuous line corresponds to the subgroup with APACHE II score <25 (blue = hydrocortisone, red = placebo). Dashed line corresponds to the subgroup with APACHE score ≥25 (blue = hydrocortisone, red = placebo). After adjustment for the presence of vasopressor-dependent shock and Lung Injury Score, in the subgroup with APACHE score <25 (n = 126), the HR for probability of survival at 28 days was 0.57 (95 % CI 0.24–1.36; p = 0.20), and at 60 days it was 0.69 (95 % CI 0.36–1.31; p = 0.25). In the subgroup with APACHE II score ≥25 (n = 71), the HR for probability of survival at 28 days was 1.05 (95 % CI 0.49–2.23; p = 0.60), and at 60 days it was 0.97 (95 % CI 0.50–1.88; p = 0.92)

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