Table 1 Patient characteristics
Characteristics | All patients (n = 468) | Phase I (n = 281) | Phase II (n = 187) | P value |
|---|---|---|---|---|
Age, years | 60.4 ± 16.2 | 59.7 ± 17.7 | 61.4 ± 13.5 | 0.255 |
Female sex, n (%) | 172 (36.8) | 103 (36.7) | 69 (36.9) | 1.000 |
APACHE II score | 26.1 ± 8.3 | 25.4 ± 8.2 | 27.2 ± 8.2 | 0.018* |
Weight, kg | 63.7 ± 17.8 | 63.7 ± 17.8 | 63.6 ± 18.0 | 0.946 |
Ventilated days preextubation, median (IQR) | 2 (1–4) | 2 (1–4) | 3 (1–5) | 0.509 |
Main diagnosis, n (%) | 0.085 | |||
Pneumonia | 130 (27.8) | 67 (23.8) | 63 (33.7) | |
Nonpneumonia sepsis | 72 (15.4) | 45 (16.0) | 27 (14.4) | |
COPD | 16 (3.4) | 7 (2.5) | 9 (4.8) | |
Asthma | 29 (6.2) | 16 (5.7) | 13 (7.0) | |
Fluid overload | 32 (6.8) | 21 (7.5) | 11 (5.8) | |
Stroke | 11 (2.4) | 10 (3.6) | 1 (0.5) | |
Seizure | 30 (6.4) | 19 (6.8) | 11 (5.9) | |
Othera | 148 (31.6) | 96 (34.2) | 52 (27.8) | |
Comorbidity, n (%) | ||||
Diabetes mellitus | 184 (39.4) | 100 (35.7) | 84 (44.9) | 0.053 |
Hypertension | 255 (54.6) | 151 (53.9) | 104 (55.6) | 0.776 |
IHD | 111 (23.8) | 60 (21.4) | 51 (27.3) | 0.151 |
CHF | 38 (8.1) | 14 (5.0) | 24 (12.8) | 0.003* |
Asthma | 66 (14.1) | 37 (13.2) | 29 (15.5) | 0.500 |
COPD | 30 (6.4) | 14 (5.0) | 16 (8.6) | 0.129 |
Bronchiectasis | 8 (1.7) | 1 (0.4) | 7 (3.7) | 0.008* |
OSA | 23 (4.9) | 12 (4.3) | 11 (5.9) | 0.514 |
CKD | 107 (23.0) | 59 (21.2) | 48 (25.7) | 0.263 |
CLD | 26 (5.6) | 18 (6.4) | 8 (4.3) | 0.411 |
Stroke | 59 (12.7) | 40 (14.3) | 19 (10.2) | 0.204 |
Cancer | 34 (12.1) | 24 (12.8) | 24 (12.8) | 0.886 |