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Table 3 The results of pooled estimates of VAE criteria for the detection of VAP

From: Does ventilator-associated event surveillance detect ventilator-associated pneumonia in intensive care units? A systematic review and meta-analysis

  Studies (n) Patients (n) Estimates (%) 95 % Confidence interval (%) Heterogeneity Publication biase Effect model
I 2 (%) P t value (Egger’s test) P
Sensitivity
 VAC 11 1633a 41.8 17.7, 65.9 99.2 <0.01 −3.53 <0.01 Random
 IVAC 6 1323a 36.3 14.4, 58.3 98.4 <0.01 −1.74 0.16 Random
 Possible VAP 2 248a 14.4 10.1, 18.8 70.6 0.07 NA NA Fixed
 Probable VAP 2 248a 1.6 0.1, 3.2 51.9 0.15 NA NA Fixed
Specificity
 VAC 9 23112b 84.5 76.6, 92.4 99.8 <0.01 −1.50 0.18 Random
 IVAC 6 14459b 94.0 91.4, 96.7 97.7 <0.01 −0.99 0.38 Random
 Possible VAP 1 8325b 97.3 96.9, 97.6 NA NA NA NA NA
 Probable VAP 1 8325b 99.3 99.1, 99.5 NA NA NA NA NA
Positive predictive value
 VAC 9 3572c 23.2 12.6, 33.9 99.1 <0.01 1.25 0.25 Random
 IVAC 5 1563c 47.2 16.1, 78.3 99.5 <0.01 0.63 0.57 Random
 Possible VAP 1 243c 7.4 4.1, 10.7 NA NA NA NA NA
 Probable VAP 1 62c 6.5 0.3, 12.6 NA NA NA NA NA
Negative predictive value
 VAC 9 20927d 95.6 94.7, 96.5 98.2 <0.01 −7.30 <0.01 Random
 IVAC 6 14211d 93.3 91.5, 95.0 99.1 <0.01 −3.89 0.02 Random
 Possible VAP 1 8165d 99.2 99.0, 99.4 NA NA NA NA NA
 Probable VAP 1 8346d 99.1 98.8, 99.3 NA NA NA NA NA
  1. aNumber of patients with ventilator-associated pneumonia (VAP). bNumber of patients without VAP. cNumber of patients in the corresponding ventilator-associated events (VAE) type. dNumber of patients in the corresponding non-VAE type. eEgger’s test was used to estimate publication bias in meta-analyses containing more than two individual studies, NA not available
  2. VAE include ventilator-associated conditions (VAC), infection-related ventilated-associated conditions (IVAC), possible VAP, and probable VAP