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Table 4 Multivariate logistic regression of association of AKI with initial serum chloride ([Cl-]0), maximal serum chloride ([Cl-]max), initial serum sodium (Na0) and maximal serum sodium(Namax)

From: Hyperchloremia and moderate increase in serum chloride are associated with acute kidney injury in severe sepsis and septic shock patients

  OR 95 % confidence interval p
Age 0.99 0.95 1.04 0.776
Sex (male) 0.40 0.09 1.77 0.228
Hypertension 0.68 0.13 3.70 0.656
APACHE II 1.55 1.19 2.03 0.001a
Serum lactate 1.60 0.84 3.04 0.155
Norepinephrine dosage 1.06 0.82 1.36 0.680
Ventilator requirement 3.95 0.57 27.44 0.165
[Cl-]0 0.87 0.70 1.10 0.240
[Cl-]max 1.28 1.02 1.62 0.037a
Δ[Cl-] 1.32 1.07 1.61 0.008a
Na0 1.01 0.76 1.35 0.825
Namax 1.03 0.81 1.31 0.825
  1. Multivariate logistic regression model was adjusted by incorporating all potentially confounding factors including age, gender, underlying diseases, initial serum lactate, APACHE II score and requirement of vasopressor and ventilator
  2. AKI acute kidney injury, OR odds ratio, APACHE Acute Physiology and Chronic Health Evaluation
  3. aIndicates statistical significance, p < 0.05