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Table 3 Univariate logistic regression model to test association of AKI and increase in serum chloride (ΔCL = [Cl-]max - CL0) in all patients and patients without hyperchloremia

From: Hyperchloremia and moderate increase in serum chloride are associated with acute kidney injury in severe sepsis and septic shock patients

Variable AKI stage 1 to 3 p AKI stage 2 and 3 p
Odds ratio (95 % CI) Odds ratio (95 % CI)
All patients
 Δ[Cl-] 1.25 (1.16–1.36) <0.001a 1.14 (1.07–1.20) <0.001a
 Δ[Cl-] ≥ 5 mmol/l 5.70 (3.00–10.82) <0.001a 3.40 (1.95–5.94) <0.001a
Patients without hyperchloremia
 Δ[Cl-] 1.37 (1.20–1.56) <0.001a 1.25 (1.13–1.38) <0.001a
 Δ[Cl-] ≥ 5 mmol/l 8.25 (3.44–19.78) <0.001a 4.77 (2.13–10.70) <0.001a
  1. AKI acute kidney injury, Δ[Cl - ] increase in serum chloride, [Cl - ] max maximal chloride concentration in the first 48 hours, [Cl - ] 0 initial chloride concentration, CI confidence interval
  2. aIndicates statistical significance, p < 0.05