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Table 5 Factors associated with an adverse outcome in the course of the disease

From: Dramatic reduction of mortality in pneumococcal meningitis

  GOS 5 GOS < 5 OR (95 % CI) P value 2015
Intracranial complications
 Cerebral ischemia 4.3 % 18.8 % 5.08 (0.57–45.47) 0.219
 Seizures 8.7 % 18.8 % 2.423 (0.44–13.28) 0.446
 Intracranial hemorrhage 0 % 6.3 % 3.85a (0.178–84.19) 0.504
 Intracranial venous thrombosis 4.3 % 9.4 % 2.27 (0.22–23.41) 0.632
 Brain edema 8.7 % 18.8 % 2.42 (0.44–13.28) 0.446
 Hydrocephalus 8.7 % 18.8 % 2.42 (0.44–13.28) 0.446
Systemic complications
 DICa 4.3 % 3.1 % 0.71 (0.04–11.98) 1.0
 Sepsis 4.3 % 25.0 % 7.33 (0.85–63.49) 0.064
 Pneumonia 8.7 % 31.3 % 4.77 (0.93–24.41) 0.055
 Renal failure 0 % 9.4 % 5.58b (0.27–113.50) 0.257
  1. aThese patients had thrombocytopenia, decreased antithrombin-III and clinical signs of bleeding (at sites of injections or mucous membranes). bOR was calculated adding 0.5 to each value. DIC disseminated intravasal coagulation, GOS Glasgow Outcome Scale