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Table 5 Factors associated with an adverse outcome in the course of the disease

From: Dramatic reduction of mortality in pneumococcal meningitis

 

GOS 5

GOS < 5

OR (95 % CI)

P value 2015

Intracranial complications

 Cerebral ischemia

4.3 %

18.8 %

5.08 (0.57–45.47)

0.219

 Seizures

8.7 %

18.8 %

2.423 (0.44–13.28)

0.446

 Intracranial hemorrhage

0 %

6.3 %

3.85a (0.178–84.19)

0.504

 Intracranial venous thrombosis

4.3 %

9.4 %

2.27 (0.22–23.41)

0.632

 Brain edema

8.7 %

18.8 %

2.42 (0.44–13.28)

0.446

 Hydrocephalus

8.7 %

18.8 %

2.42 (0.44–13.28)

0.446

Systemic complications

 DICa

4.3 %

3.1 %

0.71 (0.04–11.98)

1.0

 Sepsis

4.3 %

25.0 %

7.33 (0.85–63.49)

0.064

 Pneumonia

8.7 %

31.3 %

4.77 (0.93–24.41)

0.055

 Renal failure

0 %

9.4 %

5.58b (0.27–113.50)

0.257

  1. aThese patients had thrombocytopenia, decreased antithrombin-III and clinical signs of bleeding (at sites of injections or mucous membranes). bOR was calculated adding 0.5 to each value. DIC disseminated intravasal coagulation, GOS Glasgow Outcome Scale