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Table 3 Complications in the course of the disease

From: Dramatic reduction of mortality in pneumococcal meningitis

 

2003–2015

1984–2002

P value

Intracranial complicationsa

52.7 %

74.7 %

0.010

Brain edema

14.5 %

28.7 %

0.066

Epileptic seizures

14.5 %

27.6 %

0.098

Cerebral ischemia

12.7 %

18.4 %

0.485

Hydrocepahlus

10.9 %b

16.1 %

0.464

Sinus thrombosis

7.3 %

9.1 %

0.766

Intracranial bleeding

3.6 %

9.1 %

0.316

Cerebral vasculopthy

40 %

not assessed

 

Hearing loss

32.7 %

19.5 %

0.23

Systemic complications

34.5 %

48.3 %

0.12

Pneumonia

21.8 %

21.8 %

1.0

Sepsis

16.4 %

31.0 %

0.074

Renal failure

5.5 %

11.5 %

0.371

Disseminated intravasal coagulation

3.6 %

23 %

0.002

  1. aNot including cerebral vasculopathy, as this was not assessed in the previous study period. See main text for details. bFive of six patients required an external ventricular drain