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Table 2 Characteristics of cases identified using explicit codes (n = 138 517)

From: Use of explicit ICD9-CM codes to identify adult severe sepsis: impacts on epidemiological estimates

  Code 785.52a n = 93 380 (67 %) Code 995.92a n = 45 137 (33 %) RR (95 % CI)
Men 54 906 (58.8) 25 196 (55.8) 1.05 (1.04, 1.07)
Age group (years)
 18–44 7434 (8.0) 2921 (6.5) 1.23 (1.18, 1.28)
 45–64 22 135 (23.7) 7994 (17.7) 1.34 (1.30, 1.37)
 65–74 21 025 (22.5) 8350 (18.5) 1.22 (1.19, 1.25)
 75–84 29 374 (31.4) 14 974 (33.2) 0.95 (0.93, 0.97)
  > 84 13 412 (14.4) 10 898 (24.1) 0.59 (0.58, 0.61)
Charlson comorbidity index
 0 23 482 (25.2) 9361 (20.7) 1.21 (1.18, 1.24)
 1–2 43 180 (46.2) 20 640 (45.7) 1.01 (0.99, 1.03)
 3–4 17 029 (18.2) 9767 (21.6) 0.84 (0.82, 0.86)
  > 4 9689 (10.4) 5369 (11.9) 0.87 (0.84, 0.90)
Detailed comorbiditiesb
 Diabetes 18 184 (19.5) 11 059 (24.5) 0.79 (0.78, 0.81)
 Cancer 19 671 (21.1) 8393 (18.6) 1.13 (1.10, 1.16)
 Chronic heart failure 13 892 (14.9) 9161 (20.3) 0.73 (0.71, 0.75)
 COPD 13 488 (14.4) 7136 (15.8) 0.91 (0.89, 0.94)
 Chronic renal disease 11 327 (12.1) 6948 (15.4) 0.79 (0.76, 0.81)
 Liver disease 11 922 (12.8) 5486 (12.1) 1.05 (1.02, 1.08)
 Cerebrovascular disease 6155 (6.6) 4239 (9.4) 0.70 (0.67, 0.73)
 Dementia 4237 (4.5) 3902 (8.6) 0.52 (0.50, 0.55)
 Peripheral vascular disease 4726 (5.1) 2789 (6.2) 0.82 (0.78, 0.86)
 Acute myocardial infarction 3690 (4.0) 1897 (4.2) 0.94 (0.89, 0.99)
Surgical pathology 30 850 (33.0) 10 668 (23.6) 1.40 (1.37, 1.43)
Microbiological data
 Identified pathogensb 35 418 (37.9) 17 528 (38.8) 0.98 (0.96, 1.0)
 Gram-positive pathogens 14 318 (40.4) 7273 (41.5) 0.97 (0.95, 1.01)
 Gram-negative pathogens 24 639 (69.6) 12 126 (69.2) 1.00 (0.98, 1.03)
 Fungi 1043 (2.9) 478 (2.7) 1.08 (0.97, 1.21)
Site of infectionb
 Respiratory system 24 476 (26.2) 10 700 (23.7) 1.11 (1.08, 1.13)
 Genitourinary tract 17 462 (18.7) 11 055 (24.5) 0.76 (0.75, 0.78)
 Abdomen 12 294 (13.2) 3884 (8.6) 1.53 (1.47, 1.58)
 Procedure- related 9448 (10.1) 4160 (9.2) 1.10 (1.06, 1.14)
 Soft tissue 3483 (3.7) 1802 (4.0) 0.93 (0.88, 0.99)
 Central nervous system 991 (1.1) 434 (1.0) 1.10 (0.98, 1.24)
 Cardiovascular system 884 (1.0) 398 (0.9) 1.07 (0.95, 1.21)
 Others/not specified 35 257 (37.8) 17 581 (39.0) 0.97 (0.95, 0.99)
Organ system dysfunction (number of organs)
 1 27 222 (29.1) 17 392 (38.5) 0.76 (0.74, 0.77)
 2 30 393 (32.6) 11 601 (25.7) 1.26 (1.24, 1.29)
  > 2 35 765 (38.3) 6457 (14.3) 2.68 (2.61, 2.75)
 Not specifiedc Not applicable 9687 (21.5) Not applicable
 Type of organ system dysfunctionb
 Cardiovascular 93 380 (100) 3755 (8.3) 12.0 (11.63, 12.42)
 Respiratory 47 490 (50.9) 21 190 (47.0) 1.08 (1.07, 1.10)
 Renal 38 789 (41.5) 21 403 (47.4) 0.88 (0.86, 0.89)
 Haematological 12 220 (13.1) 5080 (11.3) 1.16 (1.13, 1.20)
 Metabolic 9418 (10.1) 3978 (8.8) 1.14 (1.10, 1.19)
 Neurological 7083 (7.6) 4149 (9.2) 0.83 (0.79, 0.86)
 Hepatic 5197 (5.6) 2490 (5.5) 1.00 (0.96, 1.06)
Invasive therapeutic measures
 Mechanical ventilation 30 569 (32.7) 7881 (17.5) 1.88 (1.83, 1.92)
 Haemodialysis 9052 (9.7) 2647 (5.9) 1.65 (1.58, 1.73)
In-hospital death 50 993 (54.6) 24 502 (54.3) 1.00 (0.99, 1.02)
  1. Data presented as number of cases (%). aCode 785.52: septic shock, code 995.92: severe sepsis; bsubgroups not mutually exclusive; corgan dysfunction without number of organs specified. RR risk ratio, CI confidence interval, COPD chronic obstructive pulmonary disease