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Table 1 Baseline values between groups

From: Noninvasive ventilation for avoidance of reintubation in patients with various cough strength

  Cough peak flow ≤70 L/minute Cough peak flow >70 L/minute  
NIV (n = 108) Control (n = 72) p Valuea NIV (n = 71) Control (n = 105) p Valuea p Valueb
Age, years 73 ± 12 74 ± 13 0.68 67 ± 14 58 ± 19 <0.01c <0.01c
Females/males, n 32/76 33/39 0.04c 12/59 27/78 0.20 <0.01c
Reason for intubation
 AECOPD 74 31 <0.01c 46 26 <0.01c <0.01c
 Pneumonia 26 32 0.01c 13 36 0.03c 0.42
 ARDS 2 5 0.12 9 22 0.23 <0.01c
 Asthma 2 0 0.52 1 5 0.40 0.17
 Other 4 4 0.72 2 16 0.01c 0.04c
APACHE II score
 Upon admission 24 ± 6 23 ± 6 0.46 21 ± 6 19 ± 7 0.02c <0.01c
 At extubation 13 ± 3 13 ± 3 0.65 12 ± 3 11 ± 3 0.02c <0.01c
Intubation period before extubation, days 8 ± 12 7 ± 5 0.44 7 ± 5 5 ± 4 <0.01c 0.01c
Cough peak flow, L/minute 48 ± 14 44 ± 15 0.07 98 ± 34 108 ± 29 0.04c <0.01c
Hemoglobin, g/dl 10.8 ± 2.3 10.4 ± 2.2 0.26 11.3 ± 2.5 11.3 ± 2.4 0.97 0.01c
Secretions, ml/24 h 75 ± 45 85 ± 54 0.18 72 ± 49 77 ± 73 0.61 0.56
Suction frequency/24 h 11 ± 4 13 ± 4 <0.01c 12 ± 4 12 ± 4 0.71 0.96
GCS score 14.7 ± 1.2 14.2 ± 1.8 0.06 14.9 ± 0.1 14.9 ± 0.1 0.80 <0.01c
Physiological parameters at extubation
 pH 7.42 ± 0.05 7.43 ± 0.05 0.30 7.45 ± 0.05 7.46 ± 0.05 0.25 <0.01c
 PaCO2, mmHg 51 ± 13 45 ± 13 <0.01c 48 ± 11 39 ± 10 <0.01c <0.01c
 PaO2/FiO2 222 ± 63 269 ± 86 <0.01c 225 ± 55 265 ± 94 <0.01c 0.33
 Respiratory rate, breaths/minute 23 ± 5 23 ± 5 0.65 23 ± 6 22 ± 5 0.09 0.44
 Rapid shallow breathing index 60 ± 27 66 ± 24 0.12 55 ± 21 48 ± 23 0.06 <0.01c
 Heart rate, beats/minute 99 ± 16 93 ± 16 0.02c 100 ± 17 94 ± 15 0.01c 0.96
 Mean arterial pressure, mmHg 93 ± 13 90 ± 12 0.18 94 ± 12 93 ± 12 0.53 0.40
  1. Abbreviations: APACHE II Acute Physiology and Chronic Health Evaluation II, NIV Noninvasive ventilation, AECOPD Acute exacerbation of chronic obstructive pulmonary disease, ARDS Acute respiratory distress syndrome, GCS Glasgow Coma Scale, PaCO 2 Partial pressure of carbon dioxide in arterial blood, PaO 2 /FiO 2 Ratio of partial pressure of arterial oxygen to fraction of inspired oxygen
  2. aDifference in NIV versus control
  3. bDifference in weak versus strong cough
  4. c p < 0.05