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Table 1 Comparison of brain and spinal cord physiological parameters

From: Spinal cord injury: is monitoring from the injury site the future?

Brain parameter Spinal cord parameter Similarities Differences Reference
Intracranial pressure (ICP) Intraspinal pressure (ISP) ICP and ISP waveforms similar with same three peaks and similar Fourier transforms Injury site ISP > ISP above or below, but ICP similar throughout. ICP but not ISP reduced with mannitol or hyperventilation. [13, 17, 35, 44]
Cerebral perfusion pressure (CPP) = MAP – ICP Spinal cord perfusion pressure (SCPP) = MAP – ISP CPP and SCPP waveforms similar. CPP and SCPP can be increased with vasopressors SCPP at injury site differs from SCPP above or below, but CPP similar in brain [13, 17, 35, 44]
Optimum cerebral perfusion pressure (CPPopt) Optimum spinal cord perfusion pressure (SCPPopt) U-shape PRx vs CPP, sPRx vs SCPP. Minimum is CPPopt or SCPPopt. CPPopt and SCPPopt individualized Overall CPPopt ~75 mmHg whereas overall SCPPopt ~90 mmHg [13, 14, 17, 35, 44]
Pressure reactivity index (PRx) Spinal Pressure reactivity index (sPRx) Running correlation between MAP and ICP/ISP PRx is global, but sPRx is for injury site [13, 14, 35, 44]
Compensatory volume reserve (RAP) Spinal compensatory volume reserve (sRAP) Running correlation between mean ICP/ISP and ICP/ISP pulse amplitude RAP is global, but sRAP is for injury site [13, 14, 35, 44]