Plasma cytokines IL-6, IL-8, and IL-10 are associated with the development of acute respiratory distress syndrome in patients with severe traumatic brain injury

Table 3 Comparison of cerebrospinal fluid cytokines among patients who did or did not have acute respiratory distress syndrome (ARDS) and those who did not

Cytokine	Normal ranges (pg/mL)	ARDS median (25^th, 75^th) (min–max)	No ARDS median (25^th, 75^th) (min–max)	P value
Cytokine	Normal ranges (pg/mL)	(n = 45)	(n = 129)	P value
IL-12p70 (n = 173)	0–2	3.8 (2.3, 5.7) (0.1–54.4)	3.5 (0.9, 4.1) (0.1–45.9)	0.155
IL-10 (n = 174)	0–1.5	7.0 (4.3, 15.6) (0.2–78.4)	5.1 (3.5, 10.0) (0.2–303.7)	0.026
IL-8 (n = 173)	0–2	1203.0 (93.7, 4782.0) (3.9–32,570.0)	985.9 (72.6, 6792.0) (0.04–204,900)	0.716
IL-6 (n = 174)	0–1	1820.0 (233.3, 7083.0) (0.2–17,790.0)	609.4 (58.6, 2917.0) (0.2–76,370)	0.085
IL-1β (n = 174)	0–3	5.6 (3.7, 8.0) (0.1–74.6)	5.2 (3.5, 8.1) (0.1–82.4)	0.490
Nitric oxide (n = 172)	Not available	0.5 (0.3, 0.9) (0.01–3.6)	0.5 (0.1, 0.7) (0.01–3.98)	0.198
TNF-α (n = 174)	0–2	4.2 (2.1, 6.3) (0.3–38.8)	3.8 (2.0, 4.3) (0.3–30.3)	0.179

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