Table 2 Baseline characteristics and outcome of unmatched and matched admissions for pneumonia stratified by HIV status
Unmatched patients | Matched patientsa | ||||
|---|---|---|---|---|---|
HIV-positive (n = 30) | HIV-negative (n = 1078) | P | HIV-negative (n = 90) | P | |
Demographicsb | |||||
Age, years, mean (SD) | 51.5 (11.1) | 60.6 (16.2) | 0.001 | 50.8 (12.9) | 0.83 |
Gender, male (%) | 17 (77.3) | 604 (64.9) | 0.28 | 69 (84.1) | 0.52 |
Race: white (%) | 14 (63.6) | 831 (89.3) | 0.002 | 67 (81.7) | 0.10 |
Comorbiditiesb | |||||
Chronic renal insufficiency (%) | 2 (9.1) | 101 (10.8) | 1 | 11 (13.4) | 0.75 |
COPD (%) | 4 (18.2) | 178 (19.1) | 1 | 11 (13.4) | 0.73 |
Diabetes mellitus (%) | 3 (13.6) | 173 (18.6) | 0.59 | 14 (17.1) | 0.76 |
Hematologic malignancy (%) | 5 (22.7) | 73 (7.8) | 0.03 | 10 (12.2) | 0.30 |
Hypertension (%) | 8 (36.4) | 277 (29.8) | 0.63 | 14 (17.1) | 0.08 |
Liver cirrhosis (%) | 1 (4.5) | 16 (1.7) | 0.32 | 2 (2.4) | 1 |
Metastatic malignancy (%) | 2 (9.1) | 28 (3) | 0.16 | 2 (2.4) | 0.20 |
Non-metastatic malignancy (%) | 2 (9.1) | 96 (10.3) | 1 | 5 (6.1) | 0.64 |
Admissions | |||||
Readmission (%) | 8 (26.7) | 147 (13.6) | 0.06 | 8 (8.9) | 0.03 |
Community-acquired pneumonia (%) | 18 (60) | 565 (52.4) | 0.44 | 56 (62.2) | 1 |
Severity of disease in first 24 hours | |||||
SOFA score, median (IQR) | 6 (4–8) | 7 (3–10) | 0.30 | 7 (4-9) | 0.89 |
Organ failure (%) | 884 (82) | 25 (83.3) | 1 | 81 (90) | 0.70 |
Shock (%) | 262 (24.3) | 8 (26.7) | 0.84 | 35 (38.9) | 0.53 |
Supportive care in the first 24 hours | |||||
Mechanical ventilation (%) | 20 (66.7) | 859 (79.7) | 0.12 | 81 (90) | 0.006 |
Renal replacement therapy (%) | 2 (6.7) | 69 (6.4) | 1 | 8 (8.9) | 1 |
Outcome | |||||
Length of stay ICU, median days (IQR) | 5 (1-15) | 4 (2-9) | 0.70 | 6 (3-11) | 0.33 |
Organ failure during admission (%) | 27 (90) | 951 (88.2) | 1 | 87 (96.7) | 0.26 |
Shock during admission (%) | 14 (46.7) | 340 (31.5) | 0.10 | 35 (38.9) | 0.53 |
30-day mortality (%)b | 4 (18.2) | 244 (26.2) | 0.47 | 19 (23.2) | 0.79 |
60-day mortality (%)b | 8 (36.4) | 290 (31.1) | 0.67 | 22 (26.8) | 0.43 |
90-day mortality (%)b | 9 (40.9) | 319 (34.3) | 0.66 | 22 (26.8) | 0.30 |
1-year mortality (%)b | 11 (50) | 412 (44.3) | 0.66 | 25 (30.5) | 0.12 |