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Table 2 Baseline characteristics and outcome of unmatched and matched admissions for pneumonia stratified by HIV status

From: Impact of HIV infection on the presentation, outcome and host response in patients admitted to the intensive care unit with sepsis; a case control study

  Unmatched patients Matched patientsa
HIV-positive (n = 30) HIV-negative (n = 1078) P HIV-negative (n = 90) P
Demographicsb
 Age, years, mean (SD) 51.5 (11.1) 60.6 (16.2) 0.001 50.8 (12.9) 0.83
 Gender, male (%) 17 (77.3) 604 (64.9) 0.28 69 (84.1) 0.52
 Race: white (%) 14 (63.6) 831 (89.3) 0.002 67 (81.7) 0.10
Comorbiditiesb
 Chronic renal insufficiency (%) 2 (9.1) 101 (10.8) 1 11 (13.4) 0.75
 COPD (%) 4 (18.2) 178 (19.1) 1 11 (13.4) 0.73
 Diabetes mellitus (%) 3 (13.6) 173 (18.6) 0.59 14 (17.1) 0.76
 Hematologic malignancy (%) 5 (22.7) 73 (7.8) 0.03 10 (12.2) 0.30
 Hypertension (%) 8 (36.4) 277 (29.8) 0.63 14 (17.1) 0.08
 Liver cirrhosis (%) 1 (4.5) 16 (1.7) 0.32 2 (2.4) 1
 Metastatic malignancy (%) 2 (9.1) 28 (3) 0.16 2 (2.4) 0.20
 Non-metastatic malignancy (%) 2 (9.1) 96 (10.3) 1 5 (6.1) 0.64
Admissions
 Readmission (%) 8 (26.7) 147 (13.6) 0.06 8 (8.9) 0.03
 Community-acquired pneumonia (%) 18 (60) 565 (52.4) 0.44 56 (62.2) 1
Severity of disease in first 24 hours
 SOFA score, median (IQR) 6 (4–8) 7 (3–10) 0.30 7 (4-9) 0.89
 Organ failure (%) 884 (82) 25 (83.3) 1 81 (90) 0.70
 Shock (%) 262 (24.3) 8 (26.7) 0.84 35 (38.9) 0.53
Supportive care in the first 24 hours
 Mechanical ventilation (%) 20 (66.7) 859 (79.7) 0.12 81 (90) 0.006
 Renal replacement therapy (%) 2 (6.7) 69 (6.4) 1 8 (8.9) 1
Outcome
 Length of stay ICU, median days (IQR) 5 (1-15) 4 (2-9) 0.70 6 (3-11) 0.33
 Organ failure during admission (%) 27 (90) 951 (88.2) 1 87 (96.7) 0.26
 Shock during admission (%) 14 (46.7) 340 (31.5) 0.10 35 (38.9) 0.53
 30-day mortality (%)b 4 (18.2) 244 (26.2) 0.47 19 (23.2) 0.79
 60-day mortality (%)b 8 (36.4) 290 (31.1) 0.67 22 (26.8) 0.43
 90-day mortality (%)b 9 (40.9) 319 (34.3) 0.66 22 (26.8) 0.30
 1-year mortality (%)b 11 (50) 412 (44.3) 0.66 25 (30.5) 0.12
  1. Results are presented as number (%) unless stated otherwise. aPatients were matched for age, gender and race and compared with HIV-positive patients. bDemographics and mortality data are given for the first ICU admission during the study period; readmissions were not included, resulting in analysis from 22 HIV-positive patients, 931 HIV-negative unmatched and 82 HIV-negative matched patients. cART combination antiretroviral therapy, COPD chronic obstructive pulmonary disease, ICU intensive care unit, IQR interquartile range, SD standard deviation, SOFA Sequential Organ Failure Assessment