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Table 1 Baseline characteristics and outcome of all sepsis admissions stratified according to HIV infection status

From: Impact of HIV infection on the presentation, outcome and host response in patients admitted to the intensive care unit with sepsis; a case control study

  HIV-positive (n = 41) HIV-negative (n = 2210) P
Demographicsa
 Age, years, mean (SD) 49.6 (12) 60.4 (15.5) <0.0001
 Gender, male (%) 24 (75) 1154 (6) 0.14
 Race, white (%) 18 (56.2) 1652 (89) 0.005
Admissions
 Readmission (%) 9 (22.0) 353 (16.0) 0.39
 New HIV diagnosis (%) 6 (14.6) -- --
Severity of disease in first 24 hours
 SOFA score, median (IQR)b 7 (3-10.5) 7 (4–9) 0.38
 Organ failure (%) 35 (85.4) 1802 (81.5) 1
 Shock (%) 9 (22) 606 (27.4) 0.50
HIV disease severity and treatment
 CD4 count, cells/mm3, median (IQR)c 70 (23-346) -- --
 Viral load, cp/ml, median (IQR)d 105 (48-54916) -- --
 On cART (%) 29 (70.7) -- --
 Viral suppression (%) 18 (47.4) -- --
Outcome
 Length of ICU stay, median days (IQR) 4 (1–11) 4 (2–8) 0.47
 Organ failure during admission (%) 37 (90.2) 1915 (86.7) 0.73
 Shock during admission (%) 15 (36.6) 750 (33.9) 0.74
 30-day mortality (%)a 6 (18.8) 481 (25.9) 0.42
 60-day mortality (%)a 11 (34.4) 568 (30.6) 0.72
 90-day mortality (%)a 13 (40.6) 629 (33.9) 0.57
 1-year mortality (%)a 16 (50) 794 (42.8) 0.35
  1. aDemographic and mortality data are given for the first ICU admission during the study period; readmissions were not included, resulting in analysis of 32 HIV-positive patients and 1857 HIV-negative patients. From the total of 2251 admissions, 23 were lost to follow up at day 30 (1 %), 32 at day 60 (1.4 %), 37 at day 90 (1.6 %), and 59 at 1 year (2.6 %) after ICU admission. bThe central nervous system score was excluded from the Sequential Organ Failure Assessment (SOFA) score calculation, because of a large number of sedated patients. cCD4 counts were available for 39 admissions. In 32 patients (82 %) the CD4 count was obtained within 120 days prior to admission, and 7 patients (18 %) had a CD4 count obtained on admission or within 30 days after admission. dViral loads were available for 39 admissions. Viral suppression was defined as a viral load below the detection limit, which was <40 copies/ml or <50 copies/ml, depending on the hospital laboratory. cART combination antiretroviral therapy, IQR interquartile range, SD standard deviation