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Table 1 Comparison of general characteristics of patients with and without acute respiratory distress syndrome

From: Association of polymorphisms in genes of factors involved in regulation of splicing of cystic fibrosis transmembrane conductance regulator mRNA with acute respiratory distress syndrome in children with pneumonia

Characteristics

No ARDS

ARDS

p a

African Americans

 Age (years), median (range)

2.1 (14 days to 18.9)

5.9 (25 days to 17.9)

0.19

 Gender, n (%) male

230 (52)

19 (66)

0.15

 Comorbidities, n (%)

   

  Asthma

94 (21)

3 (10)

0.16

  Bronchopulmonary dysplasiab

9 (2)

1 (3)

0.47

  Neurological disordersc

31 (7)

5 (17)

0.06

  Sickle cell disease

54 (12)

3 (10)

>0.99

 Mortality, n (%)

0 (0)

3 (10)

<0.001

 Admitted to hospital, n (%)

274 (62)

29 (100)

<0.001

 Admitted to PICU, n (%)

15 (3)

29 (100)

<0.001

 Mechanical ventilation, n (%)

14 (3)

29 (100)

<0.001

 Hospital length of stayd, median (range)

2 (0–19)

22 (6–101)

<0.001

 PaO2/FiO2, n (%)

   

   ≤ 100

na

16 (55)

-

  101 – ≤ 200

na

8 (28)

-

  201 – ≤ 300

na

5 (17)

-

Non-Hispanic Caucasians

 Age (years), median (range)

3.7 (18 days to 17.8)

9.6 (63 days to 17.9)

<0.001

 Gender, n (%) male

151 (56)

14 (44)

0.21

 Comorbidities, n (%)

   

  Asthma

44 (16)

2 (6)

0.19

  Bronchopulmonary dysplasiab

6 (2)

0 (0)

>0.99

  Neurological disordersc

19 (7)

5 (16)

0.15

 Mortality, n (%)

0 (0)

2 (6)

0.01

 Admitted to hospital, n (%)

209 (77)

32 (100)

<0.001

 Admitted to PICU, n (%)

17 (6)

32 (100)

<0.001

 Mechanical ventilation, n (%)

12 (4)

30 (94)

<0.001

 Hospital length of stayd, median (range)

3 (0–69)

17 (6–126)

<0.001

 PaO2/FiO2, n (%)

   

   ≤ 100

na

14 (44)

-

  101 – ≤ 200

na

14 (44)

-

  201 – ≤ 300

na

4 (12)

-

  1. a p value determined by Mann–Whitney test (age, hospital length of stay) or chi-square test or Fisher’s Exact test (others); bhistory of bronchopulmonary dysplasia (no subjects were on oxygen therapy at home); cneurological disorders included seizures and/or developmental delay; dhospital length of stay in days was calculated for survivors. n = 474 for African Americans and 304 for non-Hispanic Caucasians. ARDS acute respiratory distress syndrome, PICU pediatric intensive care unit, PaO 2 /FiO 2 partial pressure of oxygen/inspired oxygen fraction, na not available