Utility of neuron-specific enolase in traumatic brain injury; relations to S100B levels, outcome, and extracranial injury severity

Table 4 Parameters correlated to S100B and NSE levels

	NSE AUC 48 h		S100B AUC 48 h
	p value	R² (coefficient)	p value	R² (coefficient)
Gender	0.937	0.000 (-)	0.862	0.000 (+)
Age	<0.001	^* 0.028 (-)	0.055	0.009 (+)
Pupil unresponsiveness	<0.001	^* 0.030 (+)	<0.001	^* 0.032 (+)
Glasgow Coma Score (GCS) admission	0.001	0.024 (-)	<0.001	0.028 (-)
Multitrauma	<0.001	^* 0.032 (+)	0.202	0.004 (+)
Hypoxemia scene of accident (SoA)	0.015	0.014 (+)	<0.001	^* 0.038 (+)
Hypotension SoA	0.237	0.003 (+)	0.430	0.001 (+)
Glucose admission	0.022	0.012 (+)	0.005	0.018 (+)
Hemoglobin admission	0.072	0.008 (+)	0.258	0.003 (-)
Head Abbreviated Injury Score (AIS)	0.123	0.006 (+)	0.033	0.011 (+)
Marshall CT classification	0.931	0.000 (+)	0.207	0.004 (+)
Rotterdam CT score	0.006	0.018 (+)	<0.001	0.045 (+)
Stockholm CT score	0.001	0.029 (+)	<0.001	0.060 (+)
Stockholm subarachnoid hemorrhage (SAH) score	<0.001	^* 0.074 (+)	<0.001	^* 0.098 (+)
Model explained (adjusted R²)		0.195		0.161

Table illustrating which parameters that were correlated to S100B and neuron-specific enolase (NSE) levels using linear univariate and multivariate models. Bold indicates significance (p <0.05). The asterisk (^*) highlights which parameters were independently correlated to the levels of each biomarker. Adjusted-R² and coefficient are shown to facilitate comparison and interpretation

ISSN: 1364-8535